Reference

Lead-inhibited adenylate cyclase: a model for the evaluation of chelating agents in the treatment of CNS lead toxicity

Lead-inhibited adenylate cyclase: a model for the evaluation of chelating agents in the treatment of CNS lead toxicity. Nathanson, James A. (Sch. Med., Yale Univ., New Haven, Conn., USA). J. Pharm. Pharmacol., 29(8), 511-13 (English) 1977. CODEN: JPPMAB. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Addn. of 10.mu.M PbCl2 [7758-95-4] to rat cerebellar cortex homogenates reduced adenylate cyclase [9012-42-4] activity to 42% that of controls; 30.mu.M EDTA [60-00-4], 100.mu.M meso-2,3-dimercaptosuccinic acid [304-55-2], and 300.mu.M BAL [59-52-9] completely reactivated enzyme activity. Penicillamine [52-67-5] (100.mu.M) and 10mM .beta.-mercaptoethanol [60-24-2] restored 50% of the enzyme activity but higher concns. did not restore activity completely. The method may be useful for the initial screening of chelating agents for use in the treatment of CNS Pb toxicity.

Electrocrystallization of lead from chloride solutions of lead(II) chloride

Electrocrystallization of lead from chloride solutions of lead(II) chloride. Khranilov, Yu. P.; Zhukovin, S. V.; Chashchina, L. G. (Kirov. Politekh. Inst., Kirov, USSR). Deposited Doc., SPSTL 1242 Khp-D82, 17 pp. Avail. SPSTL (Russian) 1982. DOCUMENT TYPE: Report CA Section: 72 (Electrochemistry) Section cross-reference(s): 75 In connection with the use of PbCl2 [7758-95-4] as a cathode material in batteries activated by seawater, the initial stages of Pb electrocrystn. from chloride solns. of PbCl2 were compared on different current shunts, inasmuch as the change in potential of the electrode at the moment of switching-on affects the characteristics of the water-activated battery at the beginning of discharge. The current shunts were made of polished glassy graphite, Cu and Pb. Tests were conducted in HCl-acidified (pH 0.9), Ar-deaerated solns. contg. NaCl 0.5 and PbCl2 0.002M. The galvanostatic switching method was used to study the electrocrystn. of Pb on the different substrates. The max. overvoltage obsd. during electrocrystn. of Pb in chloride solns. at the moment of switching-on is the sum of the overvoltages of transfer and crystn. during the formation of 3-dimensional nucleation sites.