Detail of "776-99-8"

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CAS Number:
776-99-8
Name:
3,4-Dimethoxyphenylacetone
Molecular Structure:
Formula:
C₁₁H₁₄O₃
Molecular Weight:
194.25
Synonyms:
2-Propanone,(3,4-dimethoxyphenyl)- (6CI,7CI);(3,4-Dimethoxyphenyl)acetone;1-(3,4-Dimethoxyphenyl)-2-propanone;3,4-Dimethoxybenzyl methyl ketone;NSC16700;
EINECS:
212-285-0
Density:
1.047 g/cm³
Boiling Point:
295.2 °C at 760 mmHg
Flash Point:
123.2 °C
Appearance:
colorless transparent liquid
Risk Codes:
36/37/38
Safety:
24/25 Details

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Reference

C(2)-Methylation abolishes DA1 dopamine agonist activity of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN): steric intolerance by the receptor: C(2)-Methylation abolishes DA1 dopamine agonist activity of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN): steric intolerance by the receptor. Nichols, David E.; Jacob, James N.; Hoffman, Andrew J.; Kohli, Jai D.; Glock, Dana (Sch. Pharm. Pharm. Sci., Purdue Univ., West Lafayette, IN 47907, USA). J. Med. Chem., 27(12), 1701-5 (English) 1984. 92544-99-5 is the cas registry number. This chemical is also mentioned in this article. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 25 2-Amino-1,2,3,4-tetrahydro-6,7-dihydroxy-2-methylnaphthalene (I) [92575-16-1], prepd. as the HBr salt [92545-03-4] in several steps from 1-(3,4-dimethoxyphenyl)-2-propanone [776-99-8], was evaluated for DA1 dopamine agonist and antagonist activity on renal blood flow in dogs and in the femoral artery for possible DA2 dopamine agonist activity. I did not produce vasodilation in the dog renal artery and was inactive as a DA1-type dopamine agonist. This is in contrast to the 2-nonmethylated homolog 2-amino-1,2,3,4-tetrahydro-6,7-dihydroxynaphthalene [53463-78-8] which is a potent DA1 agonist. In the femoral vascular bed, in 4 of 5 expts., 1 at 3-190 nmols, produced vasodilation nearly equipotent to that of N,N-dipropyldopamine. The lack of activity of I is thus attributed to the steric effect of the 2-Me group, confirming that the dopamine receptor cannot tolerate alkylation at the a-side chain C. .

1-(4'-Fluorophenyl)-4-methyl-7,8-dimethoxybenzodiazepine: 1-(4'-Fluorophenyl)-4-methyl-7,8-dimethoxybenzodiazepine. Beck, Ivan; Csondes, Janos; Rakoczi, Jozsef; E.Petocz, Lujza; Kosoczky, Ibolya; Grasser, Katalin (EGYT Gyogyszervegyeszeti Gyar, Hung.). Hung. Teljes HU 25078 O 30 May 1983, 12 pp. (Hungarian). (Hungary). CODEN: HUXXBU. CLASS: IC: C07D243-28. APPLICATION: HU 78-EE2599 2 Nov 1978. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 28 1-(4'-Fluorophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine (I) [88145-29-3] is a tranquilizer and an antidepressant. The tranquilizing effect on mice (inhibition of motility and of amphetamine action, and potentiation of hexobarbital-induced narcosis) was comparable to that of tofisopam, and the antidepressant effect to that of amitryptiline. Thus, I was prepd. by the reaction of 3,4-dimethoxybenzyl Me ketone [776-99-8] with 4-fluorobenzyl chloride [352-11-4], in the presence of the anhyd. 352-11-4 and 88145-29-3 are just another two chemicals used in this study. AlCl3,conversion of the 1-(4'-fluorophenyl)-3-methyl-6,7-benzopyrilium salt formed into 2-(4'-fluorobenzoyl)-4,5-dimethoxybenzyl Me ketone, and reaction of the latter with H2NNH2×HCL in the presence of Et3N, to give I. .

Detail of "776-99-8"

3,4-Dimethoxyphenylacetone

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CAS No.776-99-8 3,4-Dimethoxyphenylacetone

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CAS No.776-99-8 3,4-Dimethoxyphenylacetone

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CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

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CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

CAS No.776-99-8 3,4-Dimethoxyphenylacetone

Reference