CAS No.777-11-7,HALOPROGIN (200 MG) Suppliers

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Basic Information

Molecular Structure:
CAS No.:	777-11-7
Name:	HALOPROGIN (200 MG)

Formula:	C₉H₄Cl₃IO
Molecular Weight:	361.394
Synonyms:	Benzene,1,2,4-trichloro-5-[(3-iodo-2-propynyl)oxy]- (9CI);Ether, 3-iodo-2-propynyl2,4,5-trichlorophenyl (7CI,8CI);2,4,5-Trichlorophenyl g-iodopropargyl ether;3-Iodo-2-propynyl 2,4,5-trichlorophenyl ether;Haloprogin;M 1028;NSC 100071;
EINECS:	212-286-6
Density:	1.959 g/cm³
Boiling Point:	391.9 °C at 760 mmHg
Flash Point:	190.8 °C
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	26-36
PSA:	9.23000
LogP:	4.42150

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Specification

The IUPAC name of Haloprogin is 1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene . With the CAS registry number 777-11-7, it is also named as (3-Iod-2-propinyl)-(2,4,5-trichlorphenyl)ether ; 2,4,5-Trichlorophenyl gamma-iodopropargil ether ; 2,4,5-Trichlorophenyl iodopropargyl ether ; 2,4,5-Trichlorophenyl-gamma-iodopropargyl ether ; 3-Iodo-2-propynyl 2,4,5-trichlorophenyl ether ; Benzene, 1,2,4-trichloro-5-((3-iodo-2-propynyl)oxy)- ; Haloprogina ; Haloprogine ; Halotex . The trade names of Haloprogin in the market are Halotex, Mycanden, Mycilan, and Polik.

The Haloprogin is light yellow or white crystal with special odor. It can be soluble in ether , chloroform , ethyl acetate , methanol , ethanol , and hot glacial acetic acid , and almost insoluble in water. As an antifungal drug, Haloprogin can be used to treat athlete's foot and other fungal infections. It was marketed over the counter primarily to treat tinea infections of the skin, and was previously used in 1% topical creams as an antifungal agent. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.

When heated to decomposition Haloprogin emits very toxic Cl⁻ and I⁻. It is harmful if swallowed and is irritative to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

The Haloprogin can be obtained by the propargyl bromide (C₃H₃Br) and 2,4,5-trichlorophenol . First, using the raw materials to get 2,4,5 - trichloro-phenyl-γ-propargyl ether by condensation, and then we obtain the product after iodization.

The other characteristics of this product can be summarized as: (1)#H bond acceptors: 1 ; (2)#H bond donors: 0 ; (3)#Freely Rotating Bonds: 2 ; (4)Index of Refraction: 1.657 ; (5)Molar Refractivity: 67.85 cm³ ; (6)Molar Volume: 184.4 cm³ ; (7)Polarizability: 26.9×10^-24 cm³ ; (8)Surface Tension: 55.4 dyne/cm ; (9)Enthalpy of Vaporization: 61.65 kJ/mol ; (10)Vapour Pressure: 5.38E-06 mmHg at 25°C. People can use the following data to convert to the molecule structure. SMILES: Clc1cc(OCC#CI)c(Cl)cc1Cl; InChI: InChI=1/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2.

The following is the toxicity data which has been texted.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intraperitoneal	250mg/kg (250mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 22, Pg. 375, 1972.
dog	LD50	oral	> 3gm/kg (3000mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology and Applied Pharmacology. Vol. 22, Pg. 375, 1972.
mouse	LD	oral	> 3gm/kg (3000mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 569, 1963.
mouse	LD	subcutaneous	> 3gm/kg (3000mg/kg)		Antimicrobial Agents and Chemotherapy Vol. -, Pg. 569, 1963.
mouse	LD50	intraperitoneal	89mg/kg (89mg/kg)		Drug and Chemical Toxicology. Vol. 13, Pg. 195, 1990.
rabbit	LD50	intraperitoneal	137mg/kg (137mg/kg)	GASTROINTESTINAL: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 22, Pg. 375, 1972.
rabbit	LD50	oral	1625mg/kg (1625mg/kg)		Toxicology and Applied Pharmacology. Vol. 22, Pg. 375, 1972.
rat	LD50	intraperitoneal	152mg/kg (152mg/kg)	GASTROINTESTINAL: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 22, Pg. 375, 1972.
rat	LD50	oral	> 5600mg/kg (5600mg/kg)		Toxicology and Applied Pharmacology. Vol. 22, Pg. 375, 1972.