Detail of "77741-66-3"

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Determination of depletion and statistical distribution of morantel-related residues in bovine milk following administration of morantel tartrate to dairy cows

Determination of depletion and statistical distribution of morantel-related residues in bovine milk following administration of morantel tartrate to dairy cows. Lynch, Martin J.; Mosher, Franklyn R.; Dimmock, Mary E.; Brunner, Linda A.; Babcock, William E.; McManus, Robert F.; Wheelhouse, Robert K. (Cent. Res. Drug Metab. Dep., Pfizer, Inc., Groton, CT 06340, USA). J. - Assoc. Off. Anal. Chem., 69(6), 935-8 (English) 1986. CODEN: JANCA2. ISSN: 0004-5756. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Section cross-reference(s): 1 Residue depletion studies were conducted in dairy cattle to monitor morantel-related residues in milk following oral administration of Rumatel (morantel tartrate) [26155-31-7]. Eleven lactating cows of various ages, periods of lactation, and known milk prodn. were orally dosed with the bolus formulation of morantel tartrate with an actual dose range of 8.4-9.8 mg/kg. Representative samples of milk were collected at 10-14 h intervals postdose, and subsamples were assayed for the major and minor hydrolysis products of morantel-related residues, N-methyl-1,3-propanediamine (MAPA) [6291-84-5] and 3-(3-methyl-2-thienyl)acrylic acid (CP-20,107) [77741-66-3]. Residues assayed as precursors of MAPA peaked at the 2nd milking (24 h post-dose) and were < 25 ppb. Precursors of CP-20,107, which confirm the identity of morantel, also peaked at 24 h postdose (2.1-3.3 ppb) and declined rapidly thereafter. A statistical model was used to project the level of residues at the upper limit of 99% of the total target animal (i.e., diary cattle) population with 95% confidence. The calcd. peak levels from this model were 50 and 5.0 ppb for morantel-related residues convertible to MAPA and CP-20,107, resp.