Reference

Process for preparing 2,4-dibromo-4- and -3-fluorobutanoic acids as well as their derivatives via the ring-opening bromination of 2-fluorocyclopropanecarboxylic acid

Process for preparing 2,4-dibromo-4- and -3-fluorobutanoic acids as well as their derivatives via the ring-opening bromination of 2-fluorocyclopropanecarboxylic acid. Lui, Norbert (Bayer A.-G., Germany). Eur. Pat. Appl. EP 755913 A1 29 Jan 1997, 8 pp. DESIGNATED STATES: R: BE, CH, DE, ES, FR, GB, IE, IT, LI, NL, PT, SE. (German). (European Patent Organization).In this article, certain chemicals are used. Some of their cas registry numbers are 7789-69-7 and 127199-13-7 CODEN: EPXXDW. CLASS: ICM: C07C051-363. ICS: C07C067-03; C07C053-21; C07C069-63. APPLICATION: EP 1996-111412 16 Jul 1996. PRIORITY: DE 1995-19527571 28 Jul 1995. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) Mixts. contg. a majority of 2,4-dibromo-4-fluorobutanoic acid and a minority of 2,4-dibromo-3-fluorobutanoic acid or their carboxylic acid derivs. are prepd. by the ring-opening bromination of (1R,2R)-, (1S,2R)-, and/or (1R,2S)-2-fluorocyclopropanecarboxylic acid and/or their corresponding acid halides in the presence of a P compd. (e.g., red P), followed by derivatization with H2O, an alkanol, or an amine. .

Preparation of amorolfine or its salts from (2E)-3-[4-(1,1-dimethylpropyl)phenyl]-N,N,N-triethyl-2-methylprop-2-ene -1-ammonium bromide and cis-2,6-dimethylmorpholine

All Rights Reserved. Preparation of amorolfine or its salts from (2E)-3-[4-(1,1-dimethylpropyl)phenyl]-N,N,N-triethyl-2-methylprop-2-ene -1-ammonium bromide and cis-2,6-dimethylmorpholine. Singh, Rakesh; Kumar, Saridi Madhava Dileep; Sathyanarayana, Swargam; Kumar, Yatendra (Ranbaxy Laboratories Limited, India). PCT Int. Appl. WO 2007000628 A1 4 Jan 2007, 14pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-IB22 9 Jan 2006. PRIORITY: IN 2005-DE41 7 Jan 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) A process for the prepn. of amorolfine or its salts from (2E)-3-[4-(1,1-dimethylpropyl)phenyl]-N,N,N-triethyl-2-methylprop-2-ene -1-ammonium bromide and cis-2,6-dimethylmorpholine is presented.Except for chemicals metioned above, 78613-38-4 and 7789-69-7 are also used. .