Reference

Compressibility and tablet-forming ability of pharmaceuticals

Compressibility and tablet-forming ability of pharmaceuticals. Jetzer, W.; Leuenberger, H.; Sucker, H. (Pharm. Inst., Univ. Basel, Basel CH-4051, Switz.). Expo. - Congr. Int. Technol. Pharm., 3rd, Volume 4, 55-65. Assoc. Pharm. Galenique Ind.: Chatenay-Malabry, Fr. (French) 1983. CODEN: 53YCA8. DOCUMENT TYPE: Conference CA Section: 63 (Pharmaceuticals) Compression equations are derived for quantifying the compressibility as well as the tablet-forming ability of drugs. The relation between the resistance to deformation of a tablet and the product (pressure against d.) is not linear. The direction of the curve is very rapid at the beginning and then gradually takes the form of a plateau. The aptitude to deformation of a substance is defined by 2 parameters, Pmax and g, representing resistance to max. deformation and susceptibility to compression, resp. The shape of the curve depends on the material used. The parameters Pmax and g are evaluated using single drugs as well as binary mixts. of aspirin [50-78-2], caffeine [58-08-2], Emcompress [7789-77-7], KBr, KCl, lactose [63-42-3] and novalgin [68-89-3].

Effect of crosslinked PVP on the properties of tableting mixtures and resultant tablets

Effect of crosslinked PVP on the properties of tableting mixtures and resultant tablets. Hermann, A. M. Guyot; Guyot, J. C. (Lab. Pharm. Galenique Biopharm., Fac. Pharm., Lille 59045, Fr.). Expo. - Congr. Int. Technol. Pharm., 3rd, Volume 4, 44-54. Assoc. Pharm. Galenique Ind.: Chatenay-Malabry, Fr. (French) 1983. CODEN: 53YCA8. DOCUMENT TYPE: Conference CA Section: 63 (Pharmaceuticals) Three different tablet formulations were prepd. each having a different drug, paracetamol [103-90-2], aspirin [50-78-2] and phenacetin [62-44-2] and contg. crosslinked poly(vinylpyrrolidone) (PVP) [9003-39-8]. Encompress [7789-77-7] was used for manuf. of directly compressed paracetamol and phenacetin tablets. Microscopic examn. of the formulations showed good adhesion of PVP particles on the drug crystals and Emcompress. The compression forces decreased with increasing PVP concns. In addn., the thickness of tablets, also decreased with increasing PVP concns. The disintegration times of the tablets were very short and they increased with increasing concn. of PVP. The dissoln. rates also increased with increasing PVP concns. A crit. concn. existed for stabilization of the formulation.