Reference

Antiviral 1-aryl-5-amino-1-penten-3-ones

Antiviral 1-aryl-5-amino-1-penten-3-ones. Ritter, Harry W.; Edwards, Michael L. (Merrell Dow Pharmaceuticals, Inc., USA). U.S. US 4400380 A 23 Aug 1983, 11 pp. Cont.-in-part of U.S. Ser. No. 165,430, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-445; A61K031-40. 917-54-4 and 779-89-5 which are cas registry numbers of chemicals are mentioned. NCL: 424248500. APPLICATION: US 81-276139 22 Jun 1981. PRIORITY: US 80-165430 2 Jul 1980. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 25, 63 Aminopentenones I [R = H, halo, C1-4 alkyl, C1-4 alkoxy, 3,4-methylenedioxy, CF3, NO2, NH2, dialkylamino, CN, OH, alkylthio, alkylsulfonyl; n = 0-3; R1, R2 independently = H, C1-4 alkyl; or NR1R2 = morpholino, piperidino, pyrrolidino, (un)substituted piperazino] were prepd. Thus, Mannich reaction of PhCH:CHCOMe with paraformaldehyde, morpholine, and HCl gave I HCl (Rn = H, NR1R2 = 4-morpholinyl), which showed antiviral activity against Herpesvirus hominis type 1 in mice. .

w-Aryl-13-prostynic acid derivatives

w-Aryl-13-prostynic acid derivatives. Collins, Waddell Paul; Pappo, Raphael (Searle, G. D., and Co., USA). Ger. Offen. DE 2758156 6 Jul 1978, 25 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07C177-00. PRIORITY: US 76-754157 27 Dec 1976. DOCUMENT TYPE: Patent CA Section: 24 (Alicyclic Compounds) Section cross-reference(s): 63 Several racemic I (R = H or C1-7 alkyl, R1, R2, and R3 = H or Me, Y = CH2CH2 or CH:CH, n = 0-3, Ar = aryl) were prepd. as abortifacients.Chemical with cas number 779-89-5 also plays role. Thus, Et3SiCHCH and BuLi were treated with benzylacetone and the product desilylated to give PhCH2CH2CH(OH)CHCH, which was protected with Et3SiCl, treated with Me 7-(3-hydroxy-5-oxo-1-cyclopenten-1-yl)heptanoate, and desilylated to give (±)-II and its 15R analog. .