Reference

Health hazard evaluation report no

Health hazard evaluation report no. HETA 82-207-1278, Garden City Engraving, Augusta, Georgia. Salisbury, S. (Natl. Inst. Occup. Saf. Health, Cincinnati, OH, USA). Report, HETA-82-207-1278; Order No. PB84-210533, 23 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1984, 84(19), 58 (English) 1983. DOCUMENT TYPE: Report CA Section: 59 (Air Pollution and Industrial Hygiene) Section cross-reference(s): 42 NIOSH conducted an industrial hygiene survey, conducted interviews, and inspected ventilation systems to evaluate headaches, eye irritation, and upper respiratory symptoms possibly related to improperly ventilated printing ink vapors. Bulk air samples of vapors released from gloss vinyl inks were qual. analyzed by gas chromatog./mass spectrometry (GC/MS) to identify ink volatiles. Personal and general area air samples were collected for anal. for PhMe [108-88-3], 2-ethoxyethyl acetate [111-15-9], diacetone alc. [123-42-2], isophorone [78-59-1], 2-butoxyethyl acetate [112-07-2], and other arom. solvent vapors such as trimethylbenzene [25551-13-7] and isopropylbenzene [98-82-8], but no exposures exceeding current OSHA stds wre found. Airborne concns. of ink vapors were below levels which would be expected to cause adverse health effects, yet recent animal studies indicating 2-ethoxyethyl acetate and other related glycol ethers are potentially embryotoxic or teratogenic at levels below current OSHA stds. highlight the need to provide adequate controls to reduce worker exposures to screen printing ink volatiles.

Quantitative evaluation of sensory-irritating and neurobehavioral properties of aliphatic ketones in mice

Quantitative evaluation of sensory-irritating and neurobehavioral properties of aliphatic ketones in mice. De Ceaurriz, J.; Micillino, J. C.; Marignac, B.; Bonnet, P.; Muller, J.; Guenier, J. P. (Dep. Pathol. Prof., Inst. Natl. Rech., Vandoeuvre 54500, Fr.). Food Chem. Toxicol., 22(7), 545-9 (English) 1984. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A decrease in respiratory rate resulting from irritation of upper airways and a decrease in duration of immobility in a behavioral despair-swimming test occurred in mice during and following short-term inhalation exposures to some commonly used aliph. ketones. Linear concn.-effect relation were obtained that allowed 2 different median active levels (MALs) to be calcd. MALs that produced a 50% decrease in respiratory rate (RD50) were calcd. as indicators of the sensory irritation potency of iso-Bu ketone [108-83-8], mesityl oxide [141-79-7], Me amyl ketone [110-43-0], Me isoamyl ketone [110-12-3], and Me Pr ketone [107-87-9]. MALs that produced a 50% decrease in immobility (ID53) were detd. for acetone [67-64-1], isophorone [78-59-1], mesityl oxide, Me amyl ketone, Me isoamyl ketone, Me iso-Bu ketone [108-10-1], and Me Pr ketone. The systematic detn. of MALs permits classification of ketones in terms of their relative potencies for eliciting a given effect. The lowest MAL indicates the primary manifestation of toxicity, against which protection should be taken. MALs assocd. with such crit. responses may be useful in the establishment of safe levels of occupational exposure to ketones, a conclusion supported by the linear relation that existed between MALs and occupational stds.