Reference

Topical anti-inflammatory and analgesic compositions containing alkanecarboxylic acid amine salts

Topical anti-inflammatory and analgesic compositions containing alkanecarboxylic acid amine salts.Some chemicals with cas registry numbers like 80636-44-8 and 80636-43-7 are also used. Eckert, Theodor (Ciba-Geigy Corp. , USA). U.S. US 4407824 A 4 Oct 1983, 9 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-14. NCL: 424329000. APPLICATION: US 81-236097 20 Feb 1981. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 25 Topical compns. contg. alkanecarboxylic and amine salts such as diethylammonium 2-(2,6-dichloroanilino)phenylacetate (I) [78213-16-8] are useful as anti-inflammatory agents and analgesics. I was prepd. by the treatment of 2-(2,6-dichloroanilino)phenylacetic acid with Et2NH in ether. An ointment was prepd. contg. I 5, propylene glycol 10-44, polyalkylene glycol 10, paraffin oil 12, petrolatum 22, microcryst. wax 7, glycerol 0-34, and parabens 0.2%. .

Topical anti-inflammatory pharmaceuticals

Topical anti-inflammatory pharmaceuticals. Asche, Henning; Affolter, Heidi (Ciba-Geigy A.-G. , Switz.). Ger. Offen. DE 3336047 A1 12 Apr 1984, 26 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K045-08; A61K031-215; A61K031-405; A61K009-10; A61K031-415. APPLICATION: DE 83-3336047 4 Oct 1983. PRIORITY: CH 82-5898 7 Oct 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A topical nonsteroid anti-inflammatory drug is formulated in an oil-in-water emulsion at pH 5-7.5. The emulsion contains: active ingredient 0.1-10, C2-4 alkanol 10-50, cosolvent 1-20, H2O 40-80, self-emulsifying lipid 3-15 (or lipids contg. 0.5-5% of an emulsifier), and gelling agent 0.5-2% by wt. An aq. phase of diethylammonium 2-(2,6-dichloroanilino)phenylacetate [78213-16-8] 1.16, iso-PrOH [67-63-0] 20, Et2NH 0.7, Carbopol 934P 1.0, Na sulfite 0.1, polyethylene glycol 300 [25322-68-3] 3.0, and H2O (to 100% of final emulsion) was emulsified with a lipid phase of Cetomacrogol 1000 2.0, paraffin oil 2.5, and Cetiol LC 2.5% at 75°.