Detail of "78582-17-9"

Reference

Inhibition of S-adenosylhomocysteine hydrolase by purine nucleotide analogs

Inhibition of S-adenosylhomocysteine hydrolase by purine nucleotide analogs. Ishikura, T.; Nakamura, H.; Sugawara, T.; Itoh, T.; Nomura, A.; Mizuno, Y. (Fac. Pharm. Sci., Hokkaido Univ., Sapporo 060, Japan). Nucleic Acids Symp. Ser., 12(Symp. Nucleic Acids Chem., 11th), 119-22 (English) 1983. CODEN: NACSD8. ISSN: 0261-3166. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 7 To find out potential inhibitors of S-adenosylhomocysteine hydrolase (SAHase) [9025-54-1], several deazaadenosine analogs and some naturally occurring nucleoside analogs were examd. with SAHases from yellow lupin seeds and rabbit liver. Neplanocin A [72877-50-0], an antibiotic, inhibited both enzymes more potently than aristeromycin [19186-33-5] which was also an antibiotic and known as one of the most potent inhibitors of SAHase. 3-Deazaadenine derivs. (2'-deoxy [78582-17-9], arabinosyl [80161-96-2], xylosyl [90655-02-0]) inhibited lupin SAHase as potently as 3-deazaadenosine [6736-58-9], whereas 1-deazaadenosine [14432-09-8] and its derivs. and 7-deazaadenosine (tubercidin) [69-33-0] were very weak.