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CAS No.: | 78607-32-6 |
---|---|
Name: | 2,5-Dichloropyridin-3-amine |
Article Data: | 8 |
Molecular Structure: | |
Formula: | C5H4Cl2N2 |
Molecular Weight: | 163.006 |
Synonyms: | 3-Amino-2,5-dichloropyridine;2,5-Dichloropyridin-3-ylamine; |
Density: | 1.498 g/cm3 |
Melting Point: | 124 °C |
Boiling Point: | 287.009 °C at 760 mmHg |
Flash Point: | 127.379 °C |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36/37/39-37/39-36 |
PSA: | 38.91000 |
LogP: | 2.55180 |
2,5-dichloro-3-nitropyridine
3-amino-2,5-dichloropyridine
Conditions | Yield |
---|---|
With formic acid; triethylamine for 24h; chemoselective reaction; | 95% |
With hydrogen In tetrahydrofuran; water at 120℃; under 37503.8 Torr; for 15h; chemoselective reaction; | 94% |
With chlorobis(cyclooctene)rhodium(I) dimer In N,N-dimethyl-formamide at 120℃; for 12h; pH=2.25; Inert atmosphere; | 86% |
2-bromo-3-amino-5-chloropyridine
3-amino-2,5-dichloropyridine
Conditions | Yield |
---|---|
With hydrogenchloride |
2-bromo-5-chloro-3-nitropyridine
3-amino-2,5-dichloropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: iron-turnings; acetic acid 2: aqueous HCl View Scheme |
2-amino-5-chloro-3-nitropyridine
3-amino-2,5-dichloropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: concentrated aqueous hydrochloric acid / -10 °C / anschliessend Behandeln mit wss. Natriumnitrit-Loesung 2: iron-turnings; acetic acid View Scheme |
5-chloro-3-nitropyridin-2-ol
3-amino-2,5-dichloropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phosphoryl chloride; phosphorus (V)-chloride 2: iron-turnings; acetic acid View Scheme | |
Multi-step reaction with 3 steps 1: bromine; phosphorus (III)-bromide 2: iron-turnings; acetic acid 3: aqueous HCl View Scheme |
Conditions | Yield |
---|---|
With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; caesium carbonate In tetrahydrofuran at 95℃; for 18h; Inert atmosphere; | 100% |
3-amino-2,5-dichloropyridine
chloroacetyl chloride
2-chloro-N-(2,5-dichloro-pyridin-3-yl)-acetamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; Inert atmosphere; | 96% |
3-amino-2,5-dichloropyridine
3-chlorobenzoate
2,5-dichloro-N-(3-chloro-phenyl)-nicotinamide
Conditions | Yield |
---|---|
In acetonitrile at 20℃; | 90% |
3-amino-2,5-dichloropyridine
4,5-dichloro-1,2,3-dithiazolium chloride
(Z)-2,5-dichloro-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-3-amine
Conditions | Yield |
---|---|
Stage #1: 3-amino-2,5-dichloropyridine; 4,5-dichloro-1,2,3-dithiazolium chloride In dichloromethane at 20℃; for 1h; Stage #2: With 2,6-dimethylpyridine In dichloromethane at 20℃; for 2h; | 82% |
3-amino-2,5-dichloropyridine
1,3,5-trimethyl-benzene
Conditions | Yield |
---|---|
With I,I-bis(acetoxy)iodobenzene at 20℃; regioselective reaction; | 82% |
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The Molecular Structure of 2,5-Dichloropyridin-3-amine (CAS NO.78607-32-6) is
Cas Register Number: 78607-32-6
IUPAC Name: 2,5-Dichloropyridin-3-amine
Synonyms: 2,5-Dichloropyridin-3-amine ; 3-Pyridinamine, 2,5-dichloro- ; 3-Amino-2,5-dichloropyridine
Molecular formula: C5H4Cl2N2
Molecular weight: 163.004660g/mol
Product Categories: pharmacetical;Amines;Pyridines;Pyridine;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Amino-pyridine series
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 16.13 Å2
Index of Refraction: 1.622
Molar Refractivity: 38.37 cm3
Molar Volume: 108.8 cm3
Surface Tension: 56.9 dyne/cm
Density: 1.497 g/cm3
Flash Point: 127.4 °C
Enthalpy of Vaporization: 52.62 kJ/mol
Boiling Point: 287 °C at 760 mmHg
Vapour Pressure of 2,5-Dichloropyridin-3-amine (CAS NO.78607-32-6): 0.00255 mmHg at 25°C
2,5-Dichloropyridin-3-amine , whose cas register No. is 78607-32-6, can be used in organic synthesis.
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S37/39:Wear suitable gloves and eye/face protection.
S36:Wear suitable protective clothing.
HazardClass: IRRITANT