Reference

Antifungal activity of four antifungal drugs in the cutaneous retention time test

Antifungal activity of four antifungal drugs in the cutaneous retention time test. Polak, Annemarie (Pharm. Res. Div., F. Hoffmann-La Roche Co. Ltd., Basel, Switz.). Sabouraudia, 22(6), 501-3 (English) 1984. CODEN: SABOA9. ISSN: 0036-2174. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Guinea pigs were topically treated with tolciclate [50838-36-3], bifonazole [60628-96-8], oxiconazole [64211-45-6] and Ro 14-4767/002 [78613-38-4] and infected on the application site with Trichophyton mentagrophytes spores at various time intervals. Tolciclate showed the highest prophylactic activity, followed by oxiconazole, Ro 14-4767/002 and bifonazole.

Preparation of amorolfine or its salts from (2E)-3-[4-(1,1-dimethylpropyl)phenyl]-N,N,N-triethyl-2-methylprop-2-ene -1-ammonium bromide and cis-2,6-dimethylmorpholine

All Rights Reserved. Preparation of amorolfine or its salts from (2E)-3-[4-(1,1-dimethylpropyl)phenyl]-N,N,N-triethyl-2-methylprop-2-ene -1-ammonium bromide and cis-2,6-dimethylmorpholine. Singh, Rakesh; Kumar, Saridi Madhava Dileep; Sathyanarayana, Swargam; Kumar, Yatendra (Ranbaxy Laboratories Limited, India). PCT Int. Appl. WO 2007000628 A1 4 Jan 2007, 14pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-IB22 9 Jan 2006. PRIORITY: IN 2005-DE41 7 Jan 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) A process for the prepn. of amorolfine or its salts from (2E)-3-[4-(1,1-dimethylpropyl)phenyl]-N,N,N-triethyl-2-methylprop-2-ene -1-ammonium bromide and cis-2,6-dimethylmorpholine is presented.Except for chemicals metioned above, 78613-38-4 and 7789-69-7 are also used. .