Reference

Transdermal tapes containing clonidines and their stabilizers

Transdermal tapes containing clonidines and their stabilizers. (Nitto Electric Industrial Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 60069013 A2 19 Apr 1985 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: A61K009-70. APPLICATION: JP 83-178959 26 Sep 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Transdermal tapes contain a layer of pressure-sensitive acrylic polymer (glass vitrification temp., -70°~-10°) bases contg. clonidine (I) [4205-90-7] (and/or its HCl salt [4205-91-8]) and 1 or more thiol compds. contg. OH and/o carboxyl group. I is stabilized by the thiol compds. Thus, 2-ethylhexyl acrylate 97 g and acrylic acid 3 g were polymd. in the presence of 0.3 g azobisisobutyronitrile. To this acrylic polymer soln. were added I and 2-mercaptopropionic acid [79-42-5], and spread over a polyurethane film and dried. The transdermal antihypertensive tape was stable when stored 3 mo at 50°.

Hydrolysis of acetylsalicylic acid catalyzed by thiols

Hydrolysis of acetylsalicylic acid catalyzed by thiols. Folkers, Gerd; Chang, Dae W.; Roth, Herrmann J. (Pharm. Inst., Univ. Tuebingen, Tuebingen 7400, Fed. Rep. Ger.). Arch. Pharm. (Weinheim, Ger.), 317(11), 962-4 (German) 1984. CODEN: ARPMAS. ISSN: 0365-6233. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The hydrolysis of acetylsalicylate [50-78-2] catalyzed by various thiols, i.e. cysteine [52-90-4], cysteamine [60-23-1], MESNA [19767-45-4], homocysteine [6027-13-0], 2-mercaptoethanol [60-24-2], and 2-mercaptopropionic acid [79-42-5] at pH 5-8 was detd. spectrophotometrically. A linear correlation was obsd. with the basicity of the thiol catalysts and the hydrolysis rate. Thus, hydrolysis rates of 0.2865 and 0.1104 ′ 10-5 m-1 were obsd. for cysteine (pKSH of 8.5) and 2-mercaptopropionic acid (pKSH of 10.0), resp.