Detail of "79055-68-8"

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Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain

Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain. Foster, Alan C.; Fagg, Graham E. (Friedrich Miescher Inst., Basel 4002, Switz.). Eur. J. Pharmacol., 133(3), 291-300 (English) 1987. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) 3H-labeled L-glutamate [56-86-0], D-aspartate [1783-96-6], D,L-2-amino-5-phosphonovalerate (D,L-AP5) [76326-31-3], and N-methyl-D-aspartate (NMDA) [6384-92-5] were evaluated as radioligands in postsynaptic d. (PSD) prepns., from rat brain. L-Glutamate had the highest affinity and greatest percentage specific binding, followed by D-aspartate > D,L-AP5 > NMDA. The pharmacol. 78966-69-5 and 78944-89-5 are also in the experiment. specificity of the binding of each radioligand indicated an interaction with NMDA-preferring receptors, the order of potency of displacing compds. tested being L-glutamate > D-aspartate > D-AP5 [79055-68-8] > D,L-AP5 > ibotenate [2552-55-8] > N-methyl-D,L-aspartate [107147-57-9] > quisqualate [52809-07-1]. For L-glutamate, the data revealed an interaction with 2 sites, the major one having NMDA receptor characteristics and the minor one resembling the quisqualate-preferring receptor. Against L-glutamate binding, quisqualate showed a 2-component inhibition profile with an affinity of 25 mM at the NMDA site and 0.19 mM at the quisqualate site. Thus, by using several radioligands possessing activity at NMDA receptors, it was confirmed that an NMDA receptor binding site is present in crude PSDs. Although it is less selective than D-[3H]aspartate, D,L-[3H]AP5, and [3H]NMDA, L-[3H]glutamate remains, by virtue of its high affinity, the ligand of choice for the study of NMDA receptors in prepns. where such sites predominate. .

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes. Olverman, H. J.; Jones, A. W.Chemicals with cas numbers 6323-99-5 and 626-69-7 also play role.; Watkins, J. C. (Dep. Pharmacol., Med. Sch., Bristol BS8 1TD, UK). Nature (London), 307(5950), 460-2 (English) 1984. CODEN: NATUAS. ISSN: 0028-0836. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) 3H-labeled D-(-)-2-amino-5-phosphonopentanoic acid (D-AP5) [79055-68-8] bound specifically to rat brain membranes, with the hippocampus and cerebral cortex being enriched in these sites relative to other brain areas. L-Glutamate [56-86-0] had a higher affinity for these receptors than all other transmitter candidates that were tested. .