Reference

Cyclosporin A enhances renin secretion and production in isolated juxtaglomerular cells

Cyclosporin A enhances renin secretion and production in isolated juxtaglomerular cells. Kurtz, Armin; Della Bruna, Roberto; Kuehn, Karlwilhelm (Physiol. Inst., Univ. Zurich, Zurich CH-8057, Switz.). Kidney Int., 33(5), 947-53 (English) 1988. CODEN: KDYIA5. ISSN: 0085-2538. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Cyclosporin A (CyA) stimulates renin secretion and renin synthesis by a direct effect on rat renal juxtaglomerular cells. This action of CyA is not mediated by changes in cellular prostaglandin or intracellular cAMP.

Successful long-term survival of pancreatic islet allografts in spontaneous or pancreatectomy-induced diabetes in dogs

Successful long-term survival of pancreatic islet allografts in spontaneous or pancreatectomy-induced diabetes in dogs. Cyclosporine-induced immune unresponsiveness. Alejandro, Rodolfo; Cutfield, Richard; Shienvold, Frances L.; Latif, Zuhair; Mintz, Daniel H. (Sch. Med., Univ. Miami, Miami, FL 33101, USA). Diabetes, 34(8, Pt. 1), 825-8 (English) 1985. CODEN: DIAEAZ. ISSN: 0012-1797. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Pancreatectomized and spontaneously diabetic dogs received canine islet allografts from 1 or more unrelated donors. The islets, enriched 30-45-fold for endocrine cells and contained in a packed cell vol. of <1.5 mL, were engrafted in the livers of recipient animals. Treatment of diabetic recipients with cyclosporine (CsA) [59865-13-3] was begun 3-5 days before islet transplantation and the initial dosage was adjusted to attain and maintain CsA serum trough levels between 400 and 600 ng/mL; five dogs with CsA levels less than this (155 ng/mL) at the time of transplantation promptly rejected their grafts, whereas rejection was encountered in only 1 of 17 diabetic animals in which the initial level >400 ng/mL. CsA was discontinued 30, 60, or 90 days after continuous therapy in 10 animals. Graft failure was obsd. 2 mo after stopping CsA in 1 animal and 5 mo in the other. Eight other islet allograft recipients have sustained fasting euglycemia for 7 and 8 mo in 2 and for at least 2 mo in the remainder. These results demonstrate that short-term CsA therapy prolongs survival of islet allografts and induces a state of immune unresponsiveness to islet alloantigens in dogs with exptl. and spontaneous diabetes.