Detail of "79775-19-2"

Reference

Lack of a role for substance P in the control of dural arterial flow

Lack of a role for substance P in the control of dural arterial flow. Carmody, John; Pawlak, Matthias; MeBlinger, Karl (School of Physiology and Pharmacology, Univ. of New South Wales, Sydney NSW 2052, Australia). Experimental Brain Research, 111(3), 424-428 (English) 1996 Springer. CODEN: EXBRAP. ISSN: 0014-4819. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The role of the neuropeptide substance P (SP) in the control of dural arterial blood flow was examd. in barbiturate-anesthetized rats. 79775-19-2 and 33507-63-0 which are cas registry numbers are also used here. The parietal skull was trephinized and the blood flow in branches of the medial meningeal artery was monitored with a laser Doppler flowmeter. Elec. stimulation of the dura mater encephali at a parasagittal site with pulses of 0.5 ms (10-20 V, 5-10 Hz, 30 s) caused a transient increase in dural blood flow which was reproducible in size with repetitive stimulation. Neither the basal flow nor the stimulus-evoked flow was significantly changed by topical administration of SP, the SP analog septide, or the NK1 antagonist RP 67580. It is concluded that SP released from dural nerve fibers upon local stimulation does not play an important role in the regulation of dural arterial flow. .

Multiple tachykinin binding sites in peripheral tissues and in brain

Multiple tachykinin binding sites in peripheral tissues and in brain. Lee, Chi Ming; Campbell, Nancy J.; Williams, Brian J.; Iversen, Leslie L. (Neurosci. Res. Cent.Some commonly used reagents like 79775-19-2 and 76260-78-1 are used in this experiment., Merck, Sharp and Dohme Res. Lab., Harlow/Essex CM20 2QR, UK). Eur. J. Pharmacol., 130(3), 209-17 (English) 1986. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Tachykinin binding sites in guinea pig urinary bladder (GPUB), rat salivary gland (RSG), hamster urinary bladder (HUB), rat vas deferens (RVD) and rat cerebral cortex (RCC) were compared using 125I-Bolton Hunter conjugates of substance P [33507-63-0] (125I-BHSP), eledoisin [69-25-0] (125I-BHE) and neurokinin A [86933-74-6] (125I-BHNKA). In typical SP-P tissues (GPUB, RSG) and in RCC, SP was the most potent displacer of 125I-BHSP and [Glp6, D-Pro9]-SP(6-11) [107382-49-0] was 90-fold less active than [Glp6,L-Pro9]-SP(6-11) [79775-19-2], whereas SP methylester (SPOMe) [76260-78-1] was 5-10-fold more active than the Bolton Hunter conjugate of SPOMe (I-BHSPOMe). On the other hand, in typical SP-E tissues (HUB, RVD), NKA was most potent in displacing 125I-BHE and [Glp6,D-Pro9]-SP(6-11) was >300-fold more active than [Glp6,L-Pro9]-SP(6-11) whereas SPOMe was 160-fold less active than I-BHSPOMe. In rat cerebral cortex, the rank order of potency of tachykinins and related analogs in displacing 125I-BHE was distinct from that of peripheral SP-E sites, with neurokinin B [86933-75-7] being the most potent displacer, and SPOMe was >1000-fold more active than I-BHSPOMe; 125I-BHE binding sites in the cerebral nervous system may represent a 3rd category of tachykinin receptor, designated SP-N. .