CAS No.80-63-7,Methyl 2-chloro-2-propenoate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	80-63-7
Name:	Methyl 2-chloro-2-propenoate
Article Data:	43

Formula:	C4H5 Cl O2
Molecular Weight:	120.535
Synonyms:	Acrylicacid, 2-chloro-, methyl ester (6CI,7CI,8CI); 2-Chloroacrylic acid methyl ester;Methyl 2-chloro-2-propenoate; Methyl 2-chloroacrylate; Methyl2-chloropropenoate; Methyl a-chloroacrylate; NSC 32608
Density:	1.189
Boiling Point:	52 °C (50 mmHg)
Flash Point:	33 °C
Hazard Symbols:	T+
Risk Codes:	R34; R26; R24/25; R10
Safety:	Moderately toxic by inhalation. Human systemic effects by inhalation: conjunctiva irritation. A severe skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻. See also ESTERS.
PSA:	26.30000
LogP:	0.91190

Synthetic route

: 89019-24-9, 108392-47-8, 108392-49-0, 113085-27-1, 113158-29-5
endo-5-Carbomethoxy-6-chloro-1,6-diazabicyclo<3.1.0>hexane

A: 80-63-7
methyl 2-chloroacrylate

B: 74-85-1
ethene

Conditions

Conditions	Yield
In chloroform-d1 at 80℃; for 10h; Product distribution;	A 95% B n/a

: 89019-24-9, 108392-47-8, 108392-49-0, 113085-27-1, 113158-29-5
exo-6-chloro-5-methoxycarbonyl-1,6-diazabicyclo<3.1.0>hexane

A: 80-63-7
methyl 2-chloroacrylate

B: 74-85-1
ethene

C N2: N2

Conditions

Conditions	Yield
In dichloromethane at 80℃; for 10h;	A 95% B n/a C n/a

...Expand

: 3674-09-7, 132854-28-5
methyl 2,3-dichloropropionate

: 80-63-7
methyl 2-chloroacrylate

Conditions

Conditions	Yield
In water; dimethyl sulfoxide at 120℃; for 6h;	91%
With 10H-phenothiazine; tetrabutylammomium bromide; sodium hydrogencarbonate In dichloromethane; water for 1.5h; Dehydrochlorination; Heating;	66%
beim Erhitzen mit protonierten Kationenaustauschern;

: 2,3,3-trichloropropene-1-ol

: 80-63-7
methyl 2-chloroacrylate

Conditions

Conditions	Yield
With sulfuric acid In methanol	74%

: 50-00-0
formaldehyd

: 96-34-4
methyl chloroacetate

: 80-63-7
methyl 2-chloroacrylate

Conditions

Conditions	Yield
Stage #1: methyl chloroacetate With Dimethyl oxalate; sodium methylate In dimethyl sulfoxide at 15 - 25℃; for 1h; Inert atmosphere; Stage #2: formaldehyd With 2,6-di-tert-butyl-4-methyl-phenol In dimethyl sulfoxide at 20 - 25℃; for 1h; Inert atmosphere;	58.1%

: 166666-36-0
methyl-α-bromo-α-chloro-propanoate

: 80-63-7
methyl 2-chloroacrylate

Conditions

Conditions	Yield
With lithium carbonate; lithium bromide In N,N-dimethyl-formamide at 70℃; for 24h;	29%

: 77825-46-8
dichloro-methylsulfanyl-acetic acid methyl ester

: 80-63-7
methyl 2-chloroacrylate

Conditions

Conditions	Yield
In tetrachloromethane at 490℃; Yield given;

: 89019-24-9, 108392-47-8, 108392-49-0, 113085-27-1, 113158-29-5
exo-6-chloro-5-methoxycarbonyl-1,6-diazabicyclo<3.1.0>hexane

A: 80-63-7
methyl 2-chloroacrylate

B: 74-85-1
ethene

Conditions

Conditions	Yield
In chloroform-d1 at 40℃; Rate constant; Mechanism; τ1/2 (h);

: 17640-02-7
methyl 2,2-dichloropropionate

: 100-52-7
benzaldehyde

A: 80-63-7
methyl 2-chloroacrylate

B: 80532-67-8
methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

Conditions

Conditions	Yield
With boron trifluoride; zinc In tetrahydrofuran at 0℃; for 24h;	A 3 % Chromat. B 76 % Chromat.

...Expand

: 100-52-7
benzaldehyde

: 166666-36-0
methyl-α-bromo-α-chloro-propanoate

A: 80-63-7
methyl 2-chloroacrylate

B: 80532-67-8
methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

C: dimethyl 2,3-dichloro-2,3-dimethylbutanedioate

Conditions

Conditions	Yield
With boron trifluoride; zinc In tetrahydrofuran at 0℃; for 3h;	A 1 % Chromat. B 85 % Chromat. C 8 % Chromat.

...Expand

Raw Materials

67280-59-5

50-00-0

3674-09-7

67-56-1

598-79-8

100-52-7

Downstream Products

51-44-5

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Chemistry

Product Name: Methyl-2-chloroacrylate (CAS NO.80-63-7)

Molecular Formula: C₄H₅ClO₂
Molecular Weight: 120.53g/mol
Mol File: 80-63-7.mol
Einecs: 201-298-7
Appearance: Clear colorless to pale yellow liquid
Boiling point: 124.6 °C at 760 mmHg
Storage Temperature: 0-6°C
Flash Point: 39.7 °C
Density: 1.155 g/cm³
Refractive index: 1.442-1.444
Surface Tension: 27.8 dyne/cm
Enthalpy of Vaporization: 36.25 kJ/mol
Vapour Pressure: 12.6 mmHg at 25°C
XLogP3-AA: 1.5
H-Bond Donor: 0
H-Bond Acceptor: 2
Product Categories: Monomer

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LC50	inhalation	500mg/m3/2H (500mg/m3)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956.
guinea pig	LC50	inhalation	500mg/m3/2H (500mg/m3)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956.
human	TCLo	inhalation	5ppm (5ppm)	SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE	"Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 90, 1968.
mouse	LC50	inhalation	500mg/m3/2H (500mg/m3)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956.
rabbit	LC50	inhalation	500mg/m3/2H (500mg/m3)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956.
rabbit	LD50	skin	270mg/kg (270mg/kg)	LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"	National Technical Information Service. Vol. OTS0535234,
rat	LC50	inhalation	500mg/m3/2H (500mg/m3)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Farmakologiya i Toksikologiya Vol. 19, Pg. 60, 1956.
rat	LD50	intraperitoneal	27mg/kg (27mg/kg)	LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"	National Technical Information Service. Vol. OTS0535234,
rat	LD50	oral	68mg/kg (68mg/kg)	LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI	National Technical Information Service. Vol. OTS0535234

Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Safety Profile

Moderately toxic by inhalation. Human systemic effects by inhalation: conjunctiva irritation. A severe skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻. See also ESTERS.
Safety Information of Methyl-2-chloroacrylate (CAS NO.80-63-7):
Hazard Codes: T+
Risk Statements: 34-26-24/25-10
10: Flammable
24: Toxic in contact with skin
25: Toxic if swallowed
26: Very Toxic by inhalation
34: Causes burns
Safety Statements: 45-38-36/37/39-26-16
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
38: In case of insufficient ventilation, wear suitable respiratory equipment
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Specification

Methyl-2-chloroacrylate ,its CAS NO. is 80-63-7,the synonyms is 2-Chloro-2-propenoicacid,methylester ; 2-Chloro-2-propenoicacimethylester ; 2-Chloroacrylic acid, methyl ester ; 2-Chloroacrylicacid,methylester ; 2-Chloro-acrylicacimethylester ; 2-Chloropropenoic acid, methyl ester ; 2-Propenoic acid, 2-chloro-, methyl ester ; Acrylic acid, 2-chloro-, methyl ester .