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8000-28-0

Basic Information
CAS No.: 8000-28-0
Name: Lavander oil
Molecular Structure:
Molecular Structure of 8000-28-0 (Lavander oil)
Formula: N/A
Molecular Weight: 0
Synonyms: Oils,essential, lavender;Oils, essential, lavender;Oils, lavender;Aromaya Raben;Bontoux 1421;Essential lavender oil;Lavandula oil;Lavender HP 83747;Lavender Liq.;Lavender essential oils;Lavender oil;Oil of Lavender;Oils,Lavandula;Oils, Lavandula officinalis;
EINECS: 289-995-2
Density: 0.93/cm3
Boiling Point: 204 °C(lit.)
Flash Point: 180 °F
Hazard Symbols: Xi
Risk Codes: 36/37/38
Safety: 23-24/25
PSA: 0.00000
LogP: 0.00000
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Chemistry

Product Name: Lavender oil
Molecular Formula: Unspecified
Synonyms of Lavender oil (CAS NO.8000-28-0): Caswell No. 618C ; EPA Pesticide Chemical Code 597600 ; FEMA No. 2619 ; FEMA No. 2622 ; Hyperabsolute lavender ; Lavander oil ; Lavandula officinalis oil ; Lavendel oel ; Lavendel oel [German] ; Lavender ; Lavender (Lavandula angustifolia) ; Lavender absolute ; Lavender concrete ; Lavender flower oil ; Lavender oil (Lavandula angustifolia) ; Oil of lavender ; Oils, lavender ; UNII-ZBP1YXW0H8
CAS NO: 8000-28-0
Classification Code: Natural Product ; Skin / Eye Irritant ; TSCA UVCB 
Boiling Point: 204 °C
Density: 0.882 g/mL at 25 °C
Refractive Index: n20/D 1.461
FEMA: 2622
Flash Point: 180 °F
Storage Temp: 2-8°C

Uses

   Lavender oil (CAS NO.8000-28-0) has long been used in the production of perfume, can also be used in aromatherapy. The scent has a calming effect which may aid in relaxation and the reduction of anxiety. Kashmir Lavender oil is also very famous as it is produced from the foothills of Himalayas.It may also help to relieve pain from tension headache when breathed in as vapor or diluted and rubbed on the skin. When added to a vaporizer, lavender oil may aid in the treatment of cough and respiratory infection.and it may also be used as a mosquito repellent when worn as perfume or when added to lotions or hair products.
 

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin > 5gm/kg (5000mg/kg)   Food and Cosmetics Toxicology. Vol. 14, Pg. 449, 1976.
mouse LD50 intraperitoneal 640mg/kg (640mg/kg)   Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite. Vol. 15, Pg. 149, 1973.
rabbit LD50 skin > 5gm/kg (5000mg/kg)   Food and Cosmetics Toxicology. Vol. 14, Pg. 451, 1976.
rat LD50 intraperitoneal 540mg/kg (540mg/kg)   Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite. Vol. 15, Pg. 149, 1973.
rat LD50 oral 4250mg/kg (4250mg/kg)   Food and Cosmetics Toxicology. Vol. 14, Pg. 449, 1976.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Safety Statements of Lavender oil (CAS NO.8000-28-0): 23-24/25 
S23: Do not breathe vapour. 
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: OF6110000
F: 8

Specification

     Lavender oil (CAS NO.8000-28-0) is an essential oil obtained by distillation from the flower spikes of certain species of lavender. Two forms are distinguished, lavender flower oil, a colorless oil, insoluble in water, having a density of 0.885 g/mL ; and lavender spike oil, a distillate from the herb Lavandula latifolia, having density 0.905 g/mL. Lavender flower oil is a designation of the National Formulary and the British Pharmacopoeia. Like all essential oils, it is not a pure compound ; it is a complex mixture of naturally occurring phytochemicals, including linalool and linalyl acetate.The primary components about it are linalool (51%) and linalyl acetate (35%).Other components include α-pinene, limonene, 1,8-cineole, cis- and trans-ocimene, 3-octanone, camphor, caryophyllene, terpinen-4-ol and lavendulyl acetate. The composition of lavender essential oil as obtained by chromotography.According to advocates of alternative medicine, lavender oil can be used as first aid and to treat a variety of common ailments.The diluted or undiluted oil may be used as an antiseptic and pain reliever to be applied to minor burns and insect bites and stings. Use only small quantities when applying directly to the skin. It is best applied on a wet cotton wool pad to the infected area.To create a massage oil which may be effective in the relief of joint and muscle pain, 1 mL of oil can be added to 1 oz. of carrier oil and rubbed liberally on the affected area. To create a chest rub for relief of asthmatic and bronchitic spasm, 1 mL of lavender oil and 5 drops of chamomile oil can be added to 10 mL of carrier oil.As a treatment for head lice, 5-10 drops of oil can be diluted in water to produce a hair rinse, while a few drops of undiluted oil can be added to a fine comb to eliminate nits.As far as serious ailments, researchers at the University of Wisconsin–Madison have found that lavender oil may have played a role in the reduction of advanced mammary tumors in lab rats. Research is on-going for potential breast, ovarian, pancreatic, liver, and prostate cancer treatments.Topically, lavender oil is cytotoxic as well as photosensitizing. A study demonstrated that lavender oil is cytotoxic to human skin cells in vitro (endothelial cells and fibroblasts) at a concentration of 0.25%. Linalool, a component of lavender oil, reflected the activity of the whole oil, indicating that linalool may be the active component of lavender oil.The result of another study showed that aqueous extracts reduced mitotic index, but induced chromosome aberrations and mitotic aberrations in comparison with control, significantly. Aqueous extracts induced breaks, stickiness, pole deviations and micronuclei. Furthermore, these effects were related to extract concentrations.However lavender should not be used within the first three months of pregnancy.