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Detail of "8001-35-2"

  • MSDS Download
  • CAS Number:
  • 8001-35-2
  • Name:
  • Toxaphene

  • Molecular Structure:
  • Molecular Weight:
  • 413.80
  • Synonyms:
  • Alltox;Anatox; Camphechlor; Camphochlor; Canfeclor; Chlorinated camphene; Estonox;Geniphene; Hercules 3956; Kamfochlor; M 5055; Melipax; PCC; PChK; PChK(insecticide); PKhF; Phenacide; Phenatox; Polychlorocamphene; Strobane T;Toxakil; Toxaphen; Toxyphen
  • Melting Point:
  • 65 - 90 C
  • Boiling Point:
  • (decomposes)
  • Solubility:
  • negligible
  • Appearance:
  • yellow waxy solid
  • Hazard Symbols:
  • Toxic by ingestion, inhalation, skin absorption; most uses prohibited. TLV: 0.5 mg/m3; STEL 1 mg/m3); animal carcinogen.
  • Risk Codes:
  • 21-25-37/38-40-50/53-67-65-38-11-36/37/38-39/23/24/25-23/24/25
  • Safety:
  • Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Human poison by ingestion and possibly other routes. Experimental poison by ingestion, intraperitoneal, and possibly other routes. Moderately toxic experimentally by inhalation and skin contact. Human systemic effects by ingestion and skin contact: somnolence, convulsions or effect on seizure threshold, coma, and allergic skin dermatitis. A skin irritant; absorbed through the skin. Experimental teratogenic and reproductive effects. Human mutation data reported. Liver injury has been reported. Lethal amounts of toxaphene can enter the body through the mouth, lungs, and skin. Systemic absorption of the insecticide is increased by the presence of digestible oils, and liquid preparations of the insecticide, which penetrate the skin more readily than do dusts and wettable powders.

    A toxic mixture of organochlorine pesticides stored to some extent in body fat. It resembles chlordane and, to some extent, camphor in its physiological action. It causes diffuse stimulation of the brain and spinal cord resulting in generalized convulsions of a tonic or clonic character. Death usually results from respiratory failure. Detoxification appears to occur in the liver. The lethal ingestion dose for humans is estimated to be 2–7 g, a toxicity of about four times that of DDT. At least seven human deaths have been reported due to toxaphene, all in children. Two families have been made ill by eating vegetables containing a large residue of toxaphene. When heated to decomposition it emits toxic fumes of Cl.

    Analytical Methods:

       

    For occupational chemical analysis use NIOSH: Chlorinated Camphene S67. Details

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Reference

Trace organic contaminants including toxaphene and trifluralin in cotton field soils from Georgia and South Carolina, USA
Trace organic contaminants including toxaphene and trifluralin in cotton field soils from Georgia and South Carolina, USA. Loganathan, Bommanna G.; Sajwan, Kenneth; Kannan, Kurunthachalam (Department of Chemistry and Center for Reservoir Research, Murray State University, Murray, KY 42071, USA). Organohalogen Compounds, 62, 352-355 (English) 2003 International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, Inc. CODEN: ORCOEP. ISSN: 1026-4892. DOCUMENT TYPE: Journal CA Section: 60 (Waste Treatment and Disposal) Section cross-reference(s): 5, 19 Organochlorine pesticide residues (DDT and its derivs., hexachlorocyclohexanes [HCH], HCB, toxaphene, trifluralin) in soil collected from cotton fields in Georgia and South Carolina were assessed. Toxaphene concns. in South Carolina cotton soil were 3.3-2500 ng/g dry wt.; those from Georgia were 9.5-269 ng/g dry wt. Trifluralin concns. in South Carolina cotton field soil were 3.3-574 ng/g, dry wt.; those from Georgia were 1-548 ng/g, dry wt. DDT residues were detected in almost all soil; HCH concns. were <1 ng/g in all soil; and HCB, polychlorinated biphenyls, and nonylphenol pollution of cotton soil was insignificant. Toxaphene, trifluralin, and DDT concns. were not proportional to org. C content, suggesting the history of the pesticide use and farm management pesticides play a major role in affecting residue levels.
Persistence and toxicity of toxaphene residues in soil
Persistence and toxicity of toxaphene residues in soil. Mirsattari, S. G. (School of Public Health, Isfahan University of Medical Sciences and Health Services, Esfahan, Iran). Pazhuhesh dar Oloome Pezeshki, 8(4), 54-60, 152 (Persian) 2003 Daneshgahe Oloome Pezeshki va Khadamate Behdashti-Darmani Ostane Isfahan. CODEN: POPABZ. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 19 Toxaphene residues were extd. from soil samples taken on 0 day, 60 days, 1 yr, 2 yr, and 3 yr following field application of toxaphene and analyzed by using gas-liq. chromatog. Then their toxicity as topical LDs for 50 percent of the animals (LD50 values) were detd. in houseflies. Field soil with an original toxaphene residue of 7.1 ppm declined to ~3.5 ppm after 3 yr. The ratio of the LD50 of 0-day, 60-day, 1-yr, 2-yr, and 3-yr soil residues to the LD50f tech. toxaphene were 1.07, 1.11, 1.23, 1.31, and 1.36. The results obtained clarify that the degrdn. and detoxification of this pesticide in soil is very slow and that toxic components may persist for a long period of time.
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