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| CAS No.: | 8002-65-1 |
|---|---|
| Name: | NEEM OIL* |
| Molecular Structure: | |
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| Formula: | W99 |
| Molecular Weight: | 0 |
| Synonyms: | Oils,glyceridic, margosa; Oils, nim; Achook; Azadirachta indica oil; Azadirachtaindica seed oil; Bioact TN; Bioblitz; Fats and Glyceridic oils, Meliaazadirachta; GreeNeem; Margosa oil; Margosa seed oil; Melia azadirachta oil;Melia azadirachta seed oil; Neem oil; Neem seed oil; Neemarin; Neemastra;Neemax; Neemicide; Nim oil; Nimbex; Oils, Azadirachta indica seed; Oils, neem;Tricure; Trilogy; Trilogy (glyceride); Vepacide; Vepacide-Tech |
| Density: | d425 0.83-0.98 |
| Flash Point: | 103 °C |
| Safety: | Slightly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Chemistry
Chemistry informtion about Neem Oil (8002-65-1) is:
Synonyms:Clarified ; Clarifiedhydrophobicextractof ; Clarifiedhydrophobicextractofneemoil ; Clarifiedhydrophobicextractofneemoilchemical ; Clarifiedhydrophobicneemoil ; Margosaoil ; nim-76 ; Nimoil
Flash Point: 103 °C
Storage temp.: 2-8°C
Refractive Index: n
Uses
In India and Bangladesh, Neem Oil (8002-65-1) can be used for preparing cosmetics (soap, hair products, body hygiene creams, hand creams) and in Ayurvedic, Unani and folklore traditional medicine, in the treatment of a wide range of afflictions. The most frequently reported indications in ancient Ayurvedic writings are skin diseases, inflammations and fevers, and more recently rheumatic disorders, insect repellent and insecticide effects.It has been used in traditional medicine for the treatment of tetanus, urticaria, eczema, scrofula and erysipelas. Traditional routes of administration of neem extracts included oral, vaginal and topical use. Neem Oil (8002-65-1) has an extensive history of human use in India and surrounding regions for a variety of therapeutic purposes. Puri (1999) has given an account of traditional uses and therapeutic indications and pharmacological studies of this oil, in his book on neem.Neem oil and other neem products such as neem leaves and neem tea should not be consumed by pregnant women, women trying to conceive, or children.But long-term use can cause liver damage.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| bird - wild | LD50 | oral | 1gm/kg (1000mg/kg) | | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. |
| rabbit | LD50 | oral | 24gm/kg (24000mg/kg) | Behavioral: somnolence (general depressed activity) behavioral: antipsychotic gastrointestinal: "hypermotility, diarrhea" | Journal of Ethnopharmacology. Vol. 23, Pg. 39, 1988. |
| rat | LD50 | oral | 14gm/kg (14000mg/kg) | Behavioral: changes in motor activity (specific assay) lungs, thorax, or respiration: dyspnea gastrointestinal: "hypermotility, diarrhea" | Journal of Ethnopharmacology. Vol. 23, Pg. 39, 1988. |
Safety Profile
Safety Statements:
S23: Do not breathe vapour.
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: QO2808000
Specification
Neem Oil (8002-65-1) is generally light to dark brown, bitter and has a rather strong odour that is said to combine the odours of peanut and garlic. It comprises mainly triglycerides and large amounts of triterpenoid compounds, which are responsible for the bitter taste. It is hydrophobic in nature and in order to emulsify it in water for application purposes, it must be formulated with appropriate surfactants.It also contains steroids (campesterol, beta-sitosterol, stigmasterol) and a plethora of triterpenoids of which Azadirachtin is the most well known and studied.