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Basic Information

Molecular Structure:
CAS No.:	804-63-7
Name:	QUININE SULFATE

Formula:	C₄₀H₅₀N₄O₈S
Molecular Weight:	746.925
Synonyms:	Quinine, sulfate (2:1) (salt) (8CI);130-95-0;QUININE;Legatrin;Quinine, sulfate (2:1) (salt);Quine;Biquinate (Bisulfate heptathydrate);QUININE SULFATE (2:1);Coco-Quinine;Quinine bisulfate;(8.alpha.,9R)-6-Methoxycinchonan-9-ol;(R)-[(4S,5S,7S)-5-ethenyl-1-azabicyclo[2.2.2]oct-7-yl]-(6-methoxyquinolin-4-yl)methanol;Quinine sulfate (VAN);Quinamm;Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-, sulfate;Aflukin;Quinine sulfate anhydrous;Quinsan (2:1 Sulfate salt), dihydrate;Quinine sulfate anhydrous [USAN];Quine (2:1 Sulfate salt, dihydrate);Cinchonan-9-ol,6'-methoxy-,(8R,9R)-,sulfate (2:1) (salt);Quinamm (2:1 Sulfate salt), dihydrate;Quinine hydrogen sulfate;Cinchonan-9-ol, 6-methoxy-, (8.alpha.,9R)-, sulfate (2:1) (salt);Dentojel (Bisulfate heptathydrate);(R)-[(5S,7S)-5-ethenyl-1-azabicyclo[2.2.2]oct-7-yl]-(6-methoxyquinolin-4-yl)methanol; sulfuric acid;Quinine, sulfate;Cinchonan-9-ol, 6-methoxy-, (8alpha,9R)-, sulfate (2:1) (salt);Quinoline alkaloid;
EINECS:	212-359-2
Density:	1.0807 (rough estimate)
Melting Point:	235.2°C
Boiling Point:	911.6 °C at 760 mmHg
Flash Point:	505.1 °C
Risk Codes:	36/37/38
Safety:	26-36
PSA:	128.57000
LogP:	3.53910

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Chemistry

Molecular structure of Quinine sulphate (CAS NO.804-63-7) is:

Product Name: Quinine sulphate
CAS Registry Number: 804-63-7
IUPAC Name: (R)-[(5R,7S)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol; sulfuric acid
Molecular Weight: 746.912 [g/mol]
Molecular Formula: C₄₀H₅₀N₄O₈S
H-Bond Donor: 4
H-Bond Acceptor: 12
EINECS: 212-359-2
Flash Point: 505.1 °C
Enthalpy of Vaporization: 138.85 kJ/mol
Boiling Point: 911.6 °C at 760 mmHg
Product Categories: Organics
Other Registry Number: 57237-58-8

Uses

Quinine sulphate (CAS NO.804-63-7) is a quinoline derivatives,can bind with the parasite's DNA to form a complex that inhibits DNA replication and RNA transcription in order to inhibit parasite protein synthesis.The role is weaker than chloroquine. In addition,it can reduce parasite oxygen consumption ,resistant Plasmodium falciparum's phosphorylase metabolism to interfere its glucose metabolism.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	4300ug/kg (4.3mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BLOOD: AGRANULOCYTOSIS	British Medical Journal. Vol. 1, Pg. 605, 1977.
man	TDLo	oral	27mg/kg (27mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 287, Pg. 1700, 1983.
man	TDLo	oral	129mg/kg (129mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE	Human Toxicology. Vol. 3, Pg. 399, 1984.
mouse	LDLo	oral	800mg/kg (800mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 78, Pg. 159, 1943.
women	LDLo	oral	126mg/kg/3W-I (126mg/kg)	CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	British Journal of Clinical Practice. Vol. 46, Pg. 138, 1992.
women	LDLo	oral	220mg/kg (220mg/kg)	CARDIAC: OTHER CHANGES BLOOD: CHANGES IN SPLEEN LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	Clinical Toxicology. Vol. 7, Pg. 129, 1974.
women	TDLo	oral	6500ug/kg (6.5mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS	American Journal of Kidney Diseases. Vol. 24, Pg. 211, 1994.
women	TDLo	oral	12mg/kg/1D-I (12mg/kg)	LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"	British Medical Journal. Vol. 286, Pg. 264, 1983.
women	TDLo	oral	45455ug/kg (45.455mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED	Medical Journal of Australia. Vol. 141, Pg. 528, 1984.
women	TDLo	oral	80mg/kg (80mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 287, Pg. 1700, 1983.
women	TDLo	oral	110mg/kg (110mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR	American Journal of Emergency Medicine. Vol. 16, Pg. 214, 1998.
women	TDLo	oral	130mg/kg (130mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	American Journal of Emergency Medicine. Vol. 9, Pg. 318,

Safety Profile

RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

Specification

Quinine sulphate , its cas register number is 804-63-7. It also can be called Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-, sulfate (2:1) ; Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-, sulfate (2:1) (salt) ; Quinine, sulfate (2:1) (salt) (8CI) ; Quinine sulfate anhydrous .