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Detail of "80433-71-2"

  • CAS Number:
  • 80433-71-2
  • Name:

  • Calcium levofolinate

  • Molecular Structure:
  • Formula:
  • C20H21CaN7O7
  • Molecular Weight:
  • 511.50
  • Synonyms:
  • CL 307,782;Isovorin;Levoleucovorin calcium [USAN];Calcium N-(p-((((6S)-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1);L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), (S)-;S-Calcium levofolinate;L-Leucovorin Calcium;Calcium Levofol;
  • Melting Point:
  • 240-250 °C (dec)
  • Appearance:
  • off-white to light beige amorphous powder
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CAS No.80433-71-2 Calcium levofolinateCompetitive Product

Assay:99%  Appearance:white solid ...  Package:bag or din  Transportation:Air Express,...  Application:Antibiotic a...

C20H21CaN7O7 L-Calcium Levofolinate USP24, BP2000

Supplier:Kangrui BIO-TECH Co.,Ltd.(H.K.) [ China (Mainland)]

Silver
Supplier 1315Integral
1315

Address::3-704, Xixi Fengshang, Wensan West Road

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CAS No.80433-71-2 Calcium levofolinateCompetitive Product

Calcium levofolinate CAS No.:80433-71-2 Synonyms: Levoleucovorin calcium; Calcium N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate Molecular Formula: C20H21CaN7O7 Molecular Weight: 511.50 Product Grade Pharmaceutical Grad

Supplier:lianyungang jinkang pharmaceutical technology co., ltd. [ China (Mainland)]

Silver
SupplierManufacturer 1690Integral
1690

Tel:008651885445517

Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China

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CAS No.80433-71-2 Calcium levofolinateCompetitive Product

Supplier:KODI CHEMICAL CO., LTD [ China (Mainland)]

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Supplier 1152Integral
1152

Tel:021

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CAS No.80433-71-2 Calcium levofolinate

Supplier:Taizhou Crene Biotechnology co.ltd [ China (Mainland)]

Platinum
Supplier 1090Integral
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CAS No.80433-71-2 Calcium levofolinate

Assay:99%  Appearance:Powder  Package:25kg/drum

Supplier:HANGZHOU TOYOND BIOTECH CO., LTD [ China (Mainland)]

Platinum
SupplierHALALISOKOSHER 1590Integral
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CAS No.80433-71-2 Calcium levofolinate

Assay:99.5%  Appearance:Powder  Package:25kg/drum

Supplier:Henan Tianfu Chemical Co., Ltd. [ China (Mainland)]

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Supplier 375Integral
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CAS No.80433-71-2 Calcium levofolinate

Calcium levofolinate

Supplier:ZHEJIANG HOLYPHARM BIOTECH CO.,LTD [ China (Mainland)]

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Supplier 1585Integral
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CAS No.80433-71-2 Calcium levofolinate

L-Leucovorin Calcium

Supplier:TCS INDUSTRY LIMITED [ China (Mainland)]

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Supplier 1590Integral
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CAS No.80433-71-2 Calcium levofolinate

Assay:98%

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

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SupplierISO 3875Integral
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CAS No.80433-71-2 Calcium levofolinate

Calcium levofolinate

Supplier:CAPITAL SQUARE INTERNATIONAL INDUSTRIAL LIMITE（SHANGHAI） [ China (Mainland)]

Platinum
Supplier 945Integral
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CAS No.80433-71-2 Calcium levofolinate

Assay:EP4

Supplier:Changzhou Highassay Chemical Co., Ltd [ China (Mainland)]

Platinum
Supplier 915Integral
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Tel:+86-519-83200395 +86-0592-7256591

Address:XIXIASHU TOWN, XINBEI DISTRICT, CHANGZHOU, JIANGSU

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CAS No.80433-71-2 Calcium levofolinate

Supplier:ChemOrganic Limited [ China (Mainland)]

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Supplier 1375Integral
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Tel:0571-28183299

Address:Room 608,Building B , Zhejiang University science park, #525 Xixi Road ,hangzhou,China.

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CAS No.80433-71-2 Calcium levofolinate

Supplier:Suzhou Howsine Biological Technology Co.,Ltd [ China (Mainland)]

Platinum
Supplier 920Integral
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CAS No.80433-71-2 Calcium levofolinate

Supplier:Zhangjiagang Jianing Import & Export Co.,Ltd. [ China (Mainland)]

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Supplier 360Integral
360

Tel:086-512-55379012 13913607595

Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China

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CAS No.80433-71-2 Calcium levofolinate

Supplier:Afine Chemicals Limited [ China (Mainland)]

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Supplier 930Integral
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Tel:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

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CAS No.80433-71-2 Calcium levofolinate

Supplier:Tiantai Linda Import & Export Co., Ltd. [ China (Mainland)]

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CAS No.80433-71-2 Calcium levofolinate

Levofolinate Calcium

Supplier:Hangzhou Starshine Pharmaceutical Co., LTD [ China (Mainland)]

660Integral
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CAS No.80433-71-2 Calcium levofolinate

Supplier:HangzhouICHImp&ExpCo.,Ltd. [ China (Mainland)]

610Integral
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CAS No.80433-71-2 Calcium levofolinate

Assay:99%  Appearance:Off-White to...  Package:25kg/drumStorage:upon clents  Transportation:store in wel...  Application:Detoxifying ...

Foreign Names Calcii levofolinas (Latin) Calcium levofolinate (German) Lévofolinate de calcium (French) Levofolinato calcico (Spanish) Synonyms: CL 307,782;Isovorin;Levoleucovorin calcium [USAN];Calcium N-(p-((((6S)-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)m

Min. Order:1kgKilogram

Supplier:Kingson pharmaceutical CO.,LTD [ China (Mainland)]

309Integral
309

Tel:+86-13723860652

Address:National Biological Industry Base, Changsha, China

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CAS No.80433-71-2 Calcium levofolinate

Assay:99%  Appearance:off-white to...  Application:Resistance t...

Synonyms: Levoleucovorin calcium; Calcium N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate Molecular Weight: 511.50 Product Grade Pharmaceutical Grad

Min. Order:1Kilogram RMB:27000-27500 /Kilogram

Supplier:Hunan kingson pharmaceutical technology co.ltd [ China (Mainland)]

Manufacturer 1390Integral
1390

Tel:86-0731-82720007

Address:National Biological Industry Base, Changsha, China

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CAS No.80433-71-2 Calcium levofolinate

Chemical Name: CALCIUM LEVOFOLINATE CAS No. 80433-71-2 Molecular Formula: C20H21CaN7O7 Formula Weight: 511.5

Supplier:CHONGQING HUAPONT PHARM. CO.,LTD. [ China (Mainland)]

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CAS No.80433-71-2 Calcium levofolinate

  Application:80433-71-2

Resistance to new cancer drugs, mainly used in the treatment of osteosarcoma by the dose methotrexate after treatment with folic acid antagonist related symptoms, can also be used to treat folic acid deficiency of giant cell anemia, also can and fluorouracil used together to exte

Supplier:Hangzhou Hejin Technology Co., Ltd. [ Select your country]

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Address:Building 1, High-tech enterprise incubator, 452#, No.6 Avenue,

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CAS No.80433-71-2 Calcium levofolinate

Applications It has the following beneficial applications; 1) In plastics compounding as reinforcing functional filler in PVC building material, UPVC pipe, PE, PP, ABS etc. At ratio of 1: 1 or 1: 1.5 replacements; It typically can substitute up to 50% of existing reinforcing

Supplier:ShenZhen ZhongBaoDa Chemical Industrial Co.,Ltd. [ China (Mainland)]

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Tel:+86-755-21912556

Address:LUOHU SHENZHEN CHINA

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CAS No.80433-71-2 Calcium levofolinate

Calcium Levofolinate / CAS 80433-71-2 CAS Number:80433-71-2 Molecular Formula:C20H21CaN7O7 Molecular Weight:511.50

Supplier:Suzhou Everfortune I/E Co., Ltd [ China (Mainland)]

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CAS No.80433-71-2 Calcium levofolinate

CALCIUM LEVOFOLINATE

Supplier:kemikalieimport [ Denmark]

610Integral
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CAS No.80433-71-2 Calcium levofolinate

Supplier:FOND EVER CO.,LIMITED [ China (Mainland)]

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Address:Mogansan Road,

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CAS No.80433-71-2 Calcium levofolinate

Supplier:Beijing Apis Biotechnology Co., Ltd. [ China (Mainland)]

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Address:NO.4PUHUANGYU ROAD,FENTAI DISTRICT, BEIJING, CHINA

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CAS No.80433-71-2 Calcium levofolinate

Supplier:Cerbios-Pharma [ Switzerland]

107Integral
107

Tel:+41 91 985 63 11

Address:CERBIOS - PHARMA SA, Via Pian Scairolo 6, CH-6917 Barbengo / Lugano Switzerland

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CAS No.80433-71-2 Calcium levofolinate

Supplier:AlliChem, LLC [ United States]

610Integral
610

Tel:(410)633-1363.

Address:Allichem LLC, 6411 Beckley Street, Suite N215, Baltimore, Maryland 21224,

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CAS No.80433-71-2 Calcium levofolinate

Supplier:QIJUN ZHANG [ China (Mainland)]

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CAS No.80433-71-2 Calcium levofolinate

Supplier:ecochem international chemical broker [ Denmark]

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Tel:+45 45 42 34 36

Address:ecochem international chemical broker

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CAS No.80433-71-2 Calcium levofolinate

Supplier:Achiever Biochem Co., Ltd. [ China (Mainland)]

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Tel:+86-21-51323393

Address:Building 9, Lane 67, Libing Road, Zhangjiang High-Tech Park, Shanghai, China

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Reference

Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia
Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia. Bartyik, Katalin; Turi, Sandor; Orosz, Ferenc; Karg, Eszter (Department of Paediatrics, Albert Szent-Gyorgyi Medical School, University of Szeged, Koranyi Fasor 14-15, Szeged H-6720, Hung.). European Journal of Cancer, 40(15), 2287-2292 (English) 2004 Elsevier Ltd. CODEN: EJCAEL. ISSN: 0959-8049. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The inhibition of glyoxalase I leads to antitumor activity through the accumulation of methylglyoxal. Our earlier observations suggested that methotrexate (MTX) may affect the glyoxalase system. This prompted a serial study of the drug on this metabolic pathway. Ten children with acute lymphoid leukemia (ALL), admitted to our department between Jan. 2002 and July 2003, were enrolled. Plasma -lactate was assayed before, 24 and 72 h after the start of four consecutive MTX infusions (5 g/m2/24 h) in each patient.Several substances with their cas registry numbers 59-05-2 and 80433-71-2 may be metioned in this study. Inhibition of glyoxalase I was tested in vitro, using human erythrocyte lysates and yeast enzyme. The elevated initial plasma -lactate levels (P < 0.02) fell significantly (P < 0.001) in response to 24 h MTX infusions. In vitro, MTX, folic and folinic acids inhibited the activity of glyoxalase I. Thus, MTX seems to affect the a-oxoaldehyde metab. in vivo, as a likely consequence of glyoxalase I inhibition. This action probably contributes to the anticancer activity and toxicity of the drug. .
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