Detail of "8050-81-5"

Reference

Food, pharmaceutical, and cosmetic preservatives containing cinnamaldehyde and parabens

Food, pharmaceutical, and cosmetic preservatives containing cinnamaldehyde and parabens. Berke, Philip A.; Rosen, William E. (Sutton Laboratories, Inc., USA). PCT Int. Appl. WO 8404886 A1 20 Dec 1984, 13 pp. DESIGNATED STATES: W: JP; RW: AT, BE, CH, DE, FR, GB, LU, NL, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: IC: A61K031-235. APPLICATION: WO 84-US885 11 Jun 1984. PRIORITY: US 83-503166 10 Jun 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 17, 62 Cinnamaldehyde [104-55-2] and esters of p-hydroxybenzoic acid (parabens) are synergistic against a wide range of microorganisms that contaminate ingestible products. The cinnamaldehyde addn. also decreases the amt. of unpleasant-tasting paraben that needs to be added to the product. Cinnamaldehyde and paraben or mixts. of parabens are incorporated at ~1:10 to 4:1 ratios by either dissolving the paraben in cinnamaldehyde or by blending with a mutually compatible diluent, such as propylene glycol. Thus, com. antacids contg. Al(OH)3 and Mg(OH)2 and Al(OH)3, Mg(OH)2, and simethicone [8050-81-5] were challenge tested with Pseudomonas aeruginosa without preservative and with added 0.08% cinnamaldehyde plus 0.044% methylparaben [99-76-3] and 0.012% propylparaben [94-13-3]. The combination of cinnamaldehyde and parabens provided effective preservation against bacteria, yeast, and fungi.

Decreased bioavailability of quinidine sulfate due to interactions with adsorbent antacids and antidiarrheal mixtures

Decreased bioavailability of quinidine sulfate due to interactions with adsorbent antacids and antidiarrheal mixtures. Moustafa, Mamdouh A.; Al-Shora, Hasan I.; Gaber, M.; Gouda, M. Wafik (Coll. Pharm., King Saud Univ., Riyadh, Saudi Arabia). Int. J. Pharm., 34(3), 207-11 (English) 1987. CODEN: IJPHDE.In this article, certain chemicals are used. Some of their cas registry numbers are 8050-81-5 and 56-54-2 ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The in vitro adsorption of quinidine [56-54-2] on some com. antacid and antidiarrheal prepns. was assessed; the effect of some of these admixts. on drug adsorption in human bioavailability studies was also measured usingqsalivary secretion data. The adsorption of quinidine on Kaopectate [8047-39-0] (kaolin-pectin suspensions(25.8 mg/g) and Mg trisilicate (23.6 mg/g) was greater than that on Simeco tablets (Al(OH)3, MgCO3, Mg(OH)2 and simethicone [8050-81-5]) (5.8 mg/g) or Bi subnitrate (3.3 mg/g). Salivary quinidine concns. decreased by 54% and the AUC by 58%, compared with control data, during the quinidine-Kaopectate interaction in vivo. This latter finding suggests a need for clin. monitoring of patients taking quinidine concomitantly with this type of adsorbent-antacid-antidiarrheal formulation. .