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| CAS No.: | 8051-02-3 |
|---|---|
| Name: | VERATRINE |
| Molecular Structure: | |
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| Formula: | C36H51NO11 |
| Molecular Weight: | 673.8 |
| Synonyms: | Veratrine |
| Density: | 1.37g/cm3 |
| Melting Point: | 130°C |
| Boiling Point: | 668.2oCat 760 |
| Flash Point: | 357.9oC |
| Hazard Symbols: |
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| Risk Codes: | 36/37/38 |
| Safety: | Human poison by ingestion. Experimental poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Ingestion causes severe gastrointestinal tract disturbances, burning in the mouth, vomiting, diarrhea, and cramps. Also produces headache, dizziness, slow pulse, and weakness. Large doses cause death by circulatory and respiratory failure. It is a powerful irritant to skin and mucous membranes. Less toxic than rotenone. Inhalation causes violent sneezing. When heated to decomposition it emits toxic fumes of NOx. Used to kill lice. |
| PSA: | 150.92000 |
| LogP: | 0.50230 |
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Chemistry
Chemistry informtion about Veratrine (CAS NO.8051-02-3) is:
Synonyms: Sabadilla Total Alkaloids ; Veratrine ; Asagraeaofficinalis ; Causticbarley ; Cevadilla ; Cevadinemixedwithveratridine
Product Categories: Alkaloids
MF: C32H49NO9
MW: 591.732760 g/mol
Density: 1.41 g/cm3
Melting Point: 130°C
Flash Point: 397.3 °C
Boiling Point: 733.3 °C at 760 mmHg
Vapour Pressure: 7.94E-25 mmHg at 25°C
Enthalpy of Vaporization: 122.19 kJ/mol
Following is the molecular structure of Veratrine (CAS NO.8051-02-3) is:
Uses
Veratrine (CAS NO.8051-02-3) is sometimes used externally, as in ointments, in the local treatment of neuralgia and rheumatism.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 17800ug/kg (17.8mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
| cat | LDLo | oral | 2500ug/kg (2.5mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| dog | LDLo | oral | 2mg/kg (2mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
| frog | LDLo | unreported | 151mg/kg (151mg/kg) | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 29, Pg. 440, 1892. | |
| guinea pig | LDLo | unreported | 1000ug/kg (1mg/kg) | Berichte der Deutschen Chemischen Gesellschaft. Vol. 37, Pg. 1946, 1904. | |
| human | LDLo | oral | 143mg/kg (143mg/kg) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 522, 1969. | |
| mouse | LD50 | intraperitoneal | 7500ug/kg (7.5mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 76, Pg. 847, 1951. | |
| mouse | LDLo | subcutaneous | 10mg/kg (10mg/kg) | behavioral: somnolence (general depressed activity) behavioral: excitement | "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933. |
| rabbit | LDLo | unreported | 500ug/kg (0.5mg/kg) | Berichte der Deutschen Chemischen Gesellschaft. Vol. 37, Pg. 1946, 1904. | |
| rat | LD50 | oral | 4gm/kg (4000mg/kg) | World Review of Pest Control. Vol. 9, Pg. 119, 1970. |
Safety Profile
Human poison by ingestion. Experimental poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Ingestion causes severe gastrointestinal tract disturbances, burning in the mouth, vomiting, diarrhea, and cramps. Also produces headache, dizziness, slow pulse, and weakness. Large doses cause death by circulatory and respiratory failure. It is a powerful irritant to skin and mucous membranes. Less toxic than rotenone. Inhalation causes violent sneezing. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
Xi
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 1544
HazardClass: 6.1(a)
PackingGroup: II
Specification
Veratrine (CAS NO.8051-02-3) is a poisonous alkaloid obtained from the root hellebore (veratrum) and from sabadilla seeds as a white crystalline powder, having an acrid, burning taste.