Detail of "80529-93-7"

Reference

Some physicochemical properties of the gadolinium-DTPA complex, a contrast agent for MRI

Some physicochemical properties of the gadolinium-DTPA complex, a contrast agent for MRI. Gries, H.; Miklautz, H. (Res. Lab., Schering A.-G., Berlin, Fed. Rep. Ger.). Physiol. Chem. Phys. Med. NMR, 16(2), 105-12 (English) 1984. CODEN: PCPNER. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The physicochem. characteristics of a good contrast agent for magnetic resonance imaging (MRI) are met by the Gd-DTPA complex [80529-93-7]. D., viscosity and osmotic pressure of solns. to be injected are reported. A short survey of the results of x-ray anal. of the Na2 Gd-DTPA is given.

Albumin labeled with gadolinium-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies

Albumin labeled with gadolinium-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies.Some chemicals with cas registry numbers like 80529-93-7 are also used. Schmiedl, Udo; Ogan, Marc; Paajanen, Hannu; Marotti, Miljenko; Crooks, Lawrence E.; Brito, Antonio C.; Brasch, Robert C. (Sch. Med., Univ. California, San Francisco, CA 94143, USA). Radiology (Easton, Pa.), 162(1), 205-10 (English) 1987. CODEN: RADLAX. ISSN: 0033-8419. DOCUMENT TYPE: Journal CA Section: 8 (Radiation Biochemistry) Human serum albumin was paramagnetically labeled by covalently binding 9-18 Gd-DTPA chelates per protein mol. This conjugate was tested in varying doses for in vivo biodistribution and effectiveness in tissue relaxation. After i.v. injection of the agent in rats, T1 relaxation times were significantly reduced in samples of the blood and in lung, heart, spleen, kidney, and brain tissue. These effects persisted at a relatively const. level for the next 30 min. In vivo magnetic resonance (MR) imaging of the heart and lungs of rats and rabbits confirmed the prolonged contrast-enhancing effect of the labeled albumin. These preliminary studies indicate that paramagnetically labeled macromols. that distribute in the intravascular space may be effective for MR imaging evaluation of tissue blood vol. .