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8053-39-2

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Basic Information
CAS No.: 8053-39-2
Name: Horse chestnut, Aesculus hippocastanum, ext.
Molecular Structure:
Molecular Structure of 8053-39-2 (Horse chestnut, Aesculus hippocastanum, ext.)
Formula: N/A
Molecular Weight: 0
Synonyms: Horse chestnut, aesculus hippocastanum, ext.;Aesculus hippocastanum (horse chestnut) seed extract;Horse chestnut;
EINECS: 232-497-7
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Chemistry

Product Name: Triterpene saponins mixture from aesculus hippocastonum L. (CAS NO.8053-39-2)
Mol File: 8053-39-2.mol
Einecs: 232-497-7

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 37mg/kg (37mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
guinea pig LD50 intravenous 940mg/kg (940mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
guinea pig LD50 oral 1120mg/kg (1120mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
mouse LD50 intraperitoneal 6700ug/kg (6.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
mouse LD50 intraperitoneal 55mg/kg (55mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 45, 1980.
mouse LD50 intravenous 14400ug/kg (14.4mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
mouse LD50 intravenous 1377mg/kg (1377mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
mouse LD50 oral 164mg/kg (164mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
mouse LD50 oral 990mg/kg (990mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
mouse LD50 subcutaneous 38500ug/kg (38.5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rabbit LD50 intravenous 30mg/kg (30mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rabbit LD50 intravenous 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rabbit LD50 oral 1530mg/kg (1530mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
rat LD50 intraperitoneal 10100ug/kg (10.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 intraperitoneal 13750mg/kg (13750mg/kg)   Drugs in Japan Vol. 6, Pg. 399, 1982.
rat LD50 intravenous 62500ug/kg (62.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rat LD50 intravenous 1450mg/kg (1450mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rat LD50 oral 833mg/kg (833mg/kg)   Yakkyoku. Pharmacy. Vol. 33, Pg. 335, 1982.
rat LD50 oral 2150mg/kg (2150mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
rat LD50 subcutaneous 150mg/kg (150mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. See also SAPONIN.

Specification

 Triterpene saponins mixture from aesculus hippocastonum L. , its CAS NO. is 8053-39-2, the synonyms are Horse chestnut, aesculus hippocastanum, ext. ; Aesculus hippocastanum (horse chestnut) seed extract ; Horse chestnut ; Triterpene saponins mixture from aesculus hippocastonum L. ; Buckeye ; Chestnut, horse .