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Demonstration of a1-adrenoceptors in human hypertrophied prostate with tritiated bunazosin

Demonstration of a1-adrenoceptors in human hypertrophied prostate with tritiated bunazosin. Moriyama, Nobuo; Kawabe, Kazuki; Hamada, Kozo; Kimura, Kiyoshi; Murahashi, Isao; Aso, Yoshio (Fac. Med., Univ. Tokyo, Tokyo 113, Japan). Acta Histochem. Cytochem., 24(4), 421-6 (English) 1991. CODEN: ACHCBO.There are some reagents like 80755-51-7 is used in this study. ISSN: 0044-5991. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The a1-adrenoceptor is considered to regulate micturition in patients with benign prostatic hypertrophy. This study demonstrated the specific binding site of [3H]bunazosin-HCl in large sections of the prostate. Surgical specimens of en bloc retropubic prostatectomy were evaluated by in vitro receptor autoradiog. Autoradiograms were assessed by using a computerized image anal. system to locate the specific binding sites. Suitable specimens were coated with emulsion for microautoradiog. Specific binding sites were recognized mainly in the perinodular regions of the prostate as well as in some nodules and in the urethral region. Ag grains were recognized in the fibromuscular stroma of the prenodular and subepithelial regions of the prostatic ducts and acini. Some epithelial cells and the basement membrane of the ducts, the acini, and the prostatic urethra also revealed the accumulation of Ag grains. Whether this latter finding indicated specific binding to a1-adrenoceptors or not is a matter for further investigation. Thus, [3H]bunazosin is useful for the qual. demonstration of specific a1-adrenoceptor binding sites in the prostate by in vitro receptor autoradiog. .

Effects of bunazosin on the electrical response of smooth muscle cells of the guinea pig mesenteric artery and vein induced by perivascular nerve stimulation and by noradrenaline

Effects of bunazosin on the electrical response of smooth muscle cells of the guinea pig mesenteric artery and vein induced by perivascular nerve stimulation and by noradrenaline. Suzuki, Hikaru; Ishikawa, Shiro; Nagao, Tetsuhiko; Komori, Kimihiro; Ibengwe, Joshwa K.; Fujioka, Masahiko (Fac. Med. 80755-51-7 and 51-41-2 are also occured in this study., Kyushu Univ., Fukuoka 812, Japan). Gen. Pharmacol., 18(2), 171-7 (English) 1987. CODEN: GEPHDP. ISSN: 0306-3623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The (-)-noradrenaline [51-41-2]-induced depolarization of smooth muscle cell membrane was blocked by bunazosin [80755-51-7] in the mesenteric artery but not in the mesenteric vein. Bunazosin enhanced the excitatory junction potential (e.j.p.) evoked in the mesenteric artery but did not modulate the slow depolarization evoked in the mesenteric vein. Application of noradrenaline decreased the amplitude of e.j.p. enhanced by bunazosin but not by yohimbine. Thus, bunazosin is a highly selective a1-adrenoceptor blocker in vascular tissues. .