Reference

Chromatographic study of vitamin B5 and its degradation products

Chromatographic study of vitamin B5 and its degradation products. Puech, A.; Monleaud, Mrs. J.; Jacob, M.; Lapiczak, G. (Lab. Pharm. Galenique, Fac. Pharm., Montpellier, Fr.). Ann. Pharm. Fr., 36(3-4), 191-5 (French) 1978. CODEN: APFRAD. ISSN: 0003-4509. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Pantothenic acid (vitamin B5) [79-83-4], some of its salts, and some of its pharmaceutical degrdn. products were thin-layer-chromatographed at 18° on silica gel GF 254 with CHCl3-EtOH-HOAc (5:3.5:1.5). The plates were dried at 100° for 10 min, sprayed with 0.1N KMnO4 (pH 10.8), and dried at 100° for 10 min. The compds. appeared as yellow spots on a pink background; Rf values and sensitivities were, resp.: pantothenic acid, 0.80, 1.00 mg; Ca pantothenate [137-08-6], 0.76, 0.50 mg; Na pantothenate [867-81-2], 0.77, 0.50 mg; panthenol [81-13-0], 0.65, 0.50 mg; pantoyl lactone [599-04-2], 0.92, 0.05 mg; b-alanine [107-95-9], 0.08, 0.10 mg. These sensitivities were as good as or better than those obtainable with ninhydrin as spray reagent. When mixts. of the above compds. were sepd. by this method, the min. amts. detectable were increased slightly in some cases, and the Rf values fluctuated slightly. However, the Ca and Na salts remained the only substances which could not be resolved.

Skin and hand protective lotion

Skin and hand protective lotion. Harke, Hans Peter; Buecklers, Lothar; Voigt, Manfred (Schuelke and Mayr G.m.b.H., Fed. Rep. Ger.). Ger. Offen. DE 3330628 A1 7 Mar 1985, 12 pp. (German). (Germany). CODEN: GWXXBX. CLASS: ICM: A61K007-40. APPLICATION: DE 83-3330628 25 Aug 1983. DOCUMENT TYPE: Patent CA Section: 62 (Essential Oils and Cosmetics) A lotion for protecting the hands of physicians, dentists, and others who must wash and disinfect them frequently, must be absorbed rapidly without leaving a film that can interfere with the gripping fine and sensitive instruments. Such a lotion contains silicone oil 1-3, partially neutralized stearic acid 3-5, mixed C16-20 fatty alcs., and ethoxylated fatty alcs. 1-2, mixed ethoxylated lanolin alcs., cetyl-stearyl alcs., and petrolatum 1-3, thickener 0.4-1, and H2O to 100 parts by wt. The lotion also can contain moisturizers inflammation inhibitors, and compds. promoting skin regeneration. A lotion contained silicone oil 1.2, stearic acid [57-11-4] 3.1, C16-20 fatty alc. and ethoxylated fatty alc. mixt. 1.0, ethoxylated lanolin alc.-cetyl-stearyl alc.-petrolatum mixt. 1.3, sorbitol [50-70-4] 1.5, Na lactate [72-17-3] 1.3, azulene [275-51-4] 0.03, bisabolol [515-69-5] 0.1, allantoin [97-59-6], 0.1, panthenol [81-13-0] 1.0, alkalihydroxide or triethanolamine 0.4-1.5, hydroxyethyl cellulose [9004-62-0] 0.8, preservative and perfume 0.3-0.8, and H2O to 100% by wt.