Reference

Effect of the prokinetic drug cisapride on gastrointestinal hormone release

Effect of the prokinetic drug cisapride on gastrointestinal hormone release. Koop, Herbert; Moennikes, H.; Koop, I.; Dionysius, J.; Schwarz, C.; Arnold, R. (Dep. Med., Philipps-Univ., Marburg D-3550, Fed. Rep. Ger.). Scand. J. Gastroenterol., 21(8), 907-13 (English) 1986. CODEN: SJGRA4. ISSN: 0036-5521. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The influence of the prokinetic drug cisapride (I) [81098-60-4] on the release of gastrointestinal hormones was studied in volunteers. Cisapride at doses of 8 mg and 20 mg i.v. increased plasma concns. of pancreatic polypeptide (hPP) [59763-91-6] by 145% and 146%, resp. Cholecystokinin (CCK) [9011-97-6] levels were increased by 176% at 8 mg cisapirde, whereas gastrin [9002-76-0] and insulin [9004-10-8] levels remained unchanged. Enhancement of PP and CCK secretion was almost completely abolished by pretreatment with 1 mg atropine. Carbachol (250 mg s.c.) increased PP release by 62% but did not affect the other hormones. Following cisapride administration for 1 wk the postprandial CCK release was diminished by 58%. Basal levels and postprandial responses of gastrin, PP, and insulin were not altered by prolonged cisapride administration. Thus, acute application of cisapride stimulates secretion of PP and CCK via atropine-sensitive mechanisms and that chronic treatment with cisapride diminishes CCK release by an unknown mechanism.

The influence of 5-hydroxytryptamine antagonists on absorptive processes in rat small intestine

The influence of 5-hydroxytryptamine antagonists on absorptive processes in rat small intestine. Hardcastle, J.; Hardcastle, P.In this study， 361-37-5 and 24219-97-4 are also used. T.; Cookson, J. (Dep. Physiol., Univ. Sheffield, Sheffield S10 2TN, UK). IRCS Med. Sci., 14(10), 986-7 (English) 1986. CODEN: IMSCE2. ISSN: 0268-8220. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 Whether luminal 5-HT [50-67-9] influences absorptive processes in small intestine was examd. using rat small intestine inverted sacs and drugs which antagonize 5-HT action. At pH 7.4, cyproheptadine [129-03-3] and mianserin [24219-97-4] decreased fluid and glycine transport by small intestine whereas methysergide [361-37-5] had no effect. At low pH (6.3), neither ketanserin [74050-98-9] nor cisapride [81098-60-4] inhibited the intestinal absorption and the inhibitory effect of cyproheptadine seen at pH 7.4 was abolished. Whereas methysergide was still without any effect, mianserin still produced inhibition but to a lower degree. The effects of these 5-HT antagonists on absorption differ from their effects on secretion where mianserin and cisapride cause an inhibition of 5-HT induced secretion while cyproheptadine and ketanserin do not, with methysergide having an effect only at a high dose. If the 5-HT antagonists act specifically on a 5-HT receptor, it is evident that different receptors are involved in the control of absorption and secretion. .