CAS No.81403-80-7,Alfuzosin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	81403-80-7
Name:	Alfuzosin
Article Data:	14

Formula:	C₁₉H₂₇N₅O₄
Molecular Weight:	389.454
Synonyms:	N-[3-[N-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-(methyl)amino]propyl]tetrahydrofuran-2-carboxamide;SL 77499;Alfuzosinum;
Density:	1.272 g/cm³
Melting Point:	178-180 °C
Appearance:	White Crystaline Powder
Risk Codes:	R20/21/22
PSA:	111.83000
LogP:	2.32280

Raw Materials

Downstream Products

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Specification

The IUPAC name of Alfuzosin is N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide. With the CAS registry number 81403-80-7, it is also named as 2-Furancarboxamide,N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino]propyl]tetrahydro-. The product's categories are APIs; Adrenoceptor, and the other registry numbers are 128707-53-9; 86163-78-2. In addition, its molecular formula is C₁₉H₂₇N₅O₄ and molecular weight is 389.45.

The other characteristics of Alfuzosin can be summarized as: (1)ACD/LogP: -1.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.43; (4)ACD/LogD (pH 7.4): -2.33; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 9; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 8; (12)Polar Surface Area: 80.26 Å²; (13)Index of Refraction: 1.62; (14)Molar Refractivity: 107.62 cm³; (15)Molar Volume: 306 cm³; (16)Polarizability: 42.66×10^-24cm³; (17)Surface Tension: 60.6 dyne/cm; (18)Density: 1.272 g/cm³.

Uses of this chemical: it is an α1 receptor antagonist which is used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. Moreover, it should be used with caution in patients with severe renal insufficiency.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(NCCCN(c2nc1cc(OC)c(OC)cc1c(n2)N)C)C3OCCC3
(2)InChI: InChI=1/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
(3)InChIKey: WNMJYKCGWZFFKR-UHFFFAOYAD
(4)Std. InChI: InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
(5)Std. InChIKey: WNMJYKCGWZFFKR-UHFFFAOYSA-N