Reference

A process for the preparation of sodium p-(12b-dihydroartemisinoxy)methylbenzoate (sodium b-artelinate)

A process for the preparation of sodium p-(12b-dihydroartemisinoxy)methylbenzoate (sodium b-artelinate). Shrimali, Meenakshi; Bhattacharya, Asish Kumar; Bhakuni, Rajendra Singh; Jain, Dharam Chand; Sharma, Ram Prakash (Council Scientific Industrial Research, India). Indian IN 185198 A 2 Dec 2000, 12 pp. 81496-81-3 and 131175-87-6 are cas registry numbers. These chemicals are also mentioned in this article. (English). (India). CODEN: INXXAP. CLASS: ICM: C07D321-10. APPLICATION: IN 1996-DE2618 29 Nov 1996. DOCUMENT TYPE: Patent CA Section: 30 (Terpenes and Terpenoids) An improved process was disclosed for the prepn. of sodium b-artelinate I (R = Na) and comprised reacting dihydroartemisinin (II) with Me 4-(hydroxymethyl)benzoate in dry benzene in presence of chlorotrimethylsilane (CIMS) and subsequently hydrolyzing the ester I (R = Me) thus formed by know methods to give acid I (R = H), and finally, grinding the acid with sodium carbonate to give desired sodium salt. .