Detail of "821-48-7"

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CAS Number:
821-48-7
Name:
Ethanamine,2-chloro-N-(2-chloroethyl)-, hydrochloride (1:1)
Superlist Name:
Bis(2-chloroethyl)amine hydrochloride
Molecular Structure:
Formula:
C₄H₉Cl₂N.HCl
Molecular Weight:
178.50
Deleted CAS:
117336-09-1
Synonyms:
N,N-Bis(2-chloroethyl)amine hydrochloride;NSC 10873;Nornitrogen mustard hydrochloride;b,b'-Dichlorodiethylamine hydrochloride;Diethylamine,2,2'-dichloro-, hydrochloride (6CI,8CI);Ethanamine, 2-chloro-N-(2-chloroethyl)-,hydrochloride (9CI);1,5-Dichloro-3-azapentane hydrochloride;2,2'-Dichlorodiethylamine hydrochloride;2-Chloro-N-(2-chloroethyl)ethanaminehydrochloride;Bis(2-chloroethyl)amine hydrochloride;Bis(2-chloroethyl)ammonium chloride;Bis(b-chloroethyl)aminehydrochloride;Leo 72a;
EINECS:
212-479-5
Melting Point:
212-214 °C(lit.)
Boiling Point:
204.2 °C at 760 mmHg
Flash Point:
77.3 °C
Solubility:
soluble in water
Appearance:
white to light beige powder
Hazard Symbols:
Xi, T, C
Risk Codes:
36/37/38-36-34
Safety:
26-45-36/37/39-27 Details
Transport Information:
UN 2811

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Reference

Mutagenic activity of major mammalian metabolites of cyclophosphamide toward several genes of Escherichia coli: Mutagenic activity of major mammalian metabolites of cyclophosphamide toward several genes of Escherichia coli. Ellenberger, Juergen; Mohn, Georges R. (Zentrallab. Mutagenitaetspruefung., Dtsch. Forschungsgem., Freiburg/Br., Ger.). J. Toxicol. Environ. Health, 3(4), 637-50 (English) 1977. CODEN: JTEHD6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 3 The cyclophosphamide (I) metabolites, 4-hydroperoxycyclophosplamide [39800-16-3], 4-ketocyclophosphamide [27046-19-1], carboxyphosphamide [22788-18-7], phosphoramide mustard [10159-53-2], and bis(2-chloroethyl)amine-HCl [821-48-7], induced mutations in E. coli cultures after treatment for 180 min at 37°. The mutations induced were forward mutations from 5-methyltryptophan sensitivity to resistance and from gal RS18 to gal+, and back mutations from arg56 to arg+. The highest mutation frequency obsd. was with arg+ mutations for all I metabolites. Apparently, the metabolic degrdn. of I produces compds. which are mutagenic.

Preparation of N-(alkyl- and arylsulfonyl)spiro[1H-indene-1,4'-piperidine] analogs as oxytocin antagonists: Preparation of N-(alkyl- and arylsulfonyl)spiro[1H-indene-1,4'-piperidine] analogs as oxytocin antagonists. Evans, Ben E.; Pettibone, Douglas J.; Freidinger, Roger M. (Merck and Co., Inc., USA). Eur. Pat.Some commonly used reagents like 821-48-7 and 137419-24-0 are used in this experiment. Appl. EP 450761 A1 9 Oct 1991, 31 pp. DESIGNATED STATES: R: CH, DE, FR, GB, IT, LI, NL. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D221-20. ICS: C07D209-96; C07D491-10; C07D471-10; C07D487-10; C07D401-06; C07D401-12; C07D401-04; A61K031-445; A61K031-40. ICI: C07D491-10, C07D307-00, C07D209-00; C07D491-10, C07D307-00, C07D221-00; C07D471-10, C07D221-00, C07D209-00; C07D487-10. APPLICATION: EP 91-301685 28 Feb 1991. PRIORITY: US 90-488343 2 Mar 1990. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 2 The title compds. [I; R4 = COR8, SO2R8, CONHR8, SO2NHR8; R8 = alkyl, (poly)cycloalkyl, (un)substituted Ph, etc.; X1 = H, alkyl, alkenyl, OH, cyano, halo, etc.; X2 = CHR10CHR11, CR10:CR11, CHR10O, CO2, etc.; X3 = (substituted) CH2, CH2CH2; R10 = (CH2)nR1; R11 = (CH2)nR2; R1, R2 = H, alkyl, pyridyl, (un)substituted Ph; n = 0-4] were prepd. Thus, (ClCH2CH2)2NCO2CMe3 was cyclocondensed with indene and the product deprotected to give spiroindene piperidine II (R4 = H) which was N-acylated with (+)-10-camphorsulfonyl chloride to give, after redn., II (R4 = hydroxybicycloheptylmethylsulfonyl group Q) (III) and the endo-isomer. III had IC50 of 0.53 mM against oxytocin receptor binding in vitro. .

Detail of "821-48-7"

Ethanamine,2-chloro-N-(2-chloroethyl)-, hydrochloride (1:1)

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CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

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CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

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CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

CAS No.821-48-7 Bis(2-chloroethyl)amine hydrochloride

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