CAS No.821-48-7,Bis(2-chloroethyl)amine hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	821-48-7
Name:	Bis(2-chloroethyl)amine hydrochloride
Article Data:	38

Formula:	C₄H₉Cl₂N.HCl
Molecular Weight:	178.489
Synonyms:	N,N-Bis(2-chloroethyl)amine hydrochloride;NSC 10873;Nornitrogen mustard hydrochloride;b,b'-Dichlorodiethylamine hydrochloride;Diethylamine,2,2'-dichloro-, hydrochloride (6CI,8CI);Ethanamine, 2-chloro-N-(2-chloroethyl)-,hydrochloride (9CI);1,5-Dichloro-3-azapentane hydrochloride;2,2'-Dichlorodiethylamine hydrochloride;2-Chloro-N-(2-chloroethyl)ethanaminehydrochloride;Bis(2-chloroethyl)amine hydrochloride;Bis(2-chloroethyl)ammonium chloride;Bis(b-chloroethyl)aminehydrochloride;Leo 72a;
EINECS:	212-479-5
Density:	1.125 g/cm3
Melting Point:	212-214 °C(lit.)
Boiling Point:	204.2 °C at 760 mmHg
Flash Point:	77.3 °C
Solubility:	soluble in water
Appearance:	white to light beige powder
Hazard Symbols:	Xi, T, C
Risk Codes:	36/37/38-36-34
Safety:	26-45-36/37/39-27
Transport Information:	UN 2811
PSA:	12.03000
LogP:	2.24650

Synthetic route

: 111-42-2
2,2'-iminobis[ethanol]

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In 1,2-dichloro-ethane at 50℃; for 3h;	100%
With thionyl chloride In dichloromethane for 24h;	100%
With thionyl chloride In chloroform at 50℃; for 4h; Temperature;	98.8%

: 50-18-0
cyclophosphamide

A: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

B: Phosphoric acid mono-(3-amino-propyl) ester; hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 37℃; pH 1.2;

: 15567-79-0
N,N,N',N'-tetrakis(2-chloroethyl)methanediamine

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

Conditions

Conditions	Yield
With acetyl chloride In dichloromethane Cooling;

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 127-88-8
N,N-di(2-chloroethyl)amidophosphoric acid dichloride

Conditions

Conditions	Yield
With trichlorophosphate for 75h; Heating;	100%
With trichlorophosphate	100%
With trichlorophosphate Heating;	93%

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 541-41-3
chloroformic acid ethyl ester

: 5467-15-2
bis(2-chloroethyl)carbamic acid ether

Conditions

Conditions	Yield
With potassium carbonate In acetone for 4h; Heating / reflux;	100%
With triethylamine In dichloromethane at 0℃; for 1.5h;	99%
With triethylamine In dichloromethane at 0℃; for 1.5h;	99%
With sodium hydroxide; water at 7 - 10℃;

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 124-63-0
methanesulfonyl chloride

: 54533-09-4
N,N-bis(2-chloroethyl)methanesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 15h;	100%
With triethylamine In dichloromethane at 20℃; for 3h;	94%
Stage #1: bis-(2-chloroethyl)amine hydrochloride With triethylamine In dichloromethane Stage #2: methanesulfonyl chloride In dichloromethane at 20℃; for 3h;	94%

: 50-00-0
formaldehyd

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 55-86-7
mechlorethamine hydrochloride

Conditions

Conditions	Yield
With formic acid at 100 - 120℃; for 3.33333h;	100%
With formic acid In water at 100 - 120℃; for 3.33333h; Heating / reflux;	100%
With formic acid In water at 100 - 120℃; for 3.33333h;	100%
With formic acid In water 1a.) 100 deg C, 3 h, 1b.) 120 deg C, 20 min; Yield given;

: 24424-99-5
di-tert-butyl dicarbonate

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 118753-70-1
N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine

Conditions

Conditions	Yield
With triethylamine	100%
In dichloromethane	100%
With sodium hydroxide In dichloromethane at 20℃; for 18.5h;	100%

: 2-chloro-N-(3-hydroxypropyl)-3,5-dinitrobenzamide

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 851627-23-1
2-[bis(2-chloroethyl)amino]-N-(3-hydroxypropyl)-3,5-dinitrobenzamide

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 50℃; for 24h;	100%

: 851627-28-6
2-chloro-N-(4-hydroxybutyl)-3,5-dinitrobenzamide

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 2-[bis(2-chloroethyl)amino]-N-(4-hydroxybutyl)-3,5-dinitrobenzamide

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 50℃; for 24h;	100%

Raw Materials

111-42-2

Downstream Products

127-88-8

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Chemistry

Bis(2-chloroethyl) (CAS NO.821-48-7) amine hydrochloride can be also named as 2,2'-dichloro-diethylaminhydrochloride;2-chloro-n-(2-chloroethyl)ethanaminehydrochloride;2-chloro-n-(2-chloroethyl)-ethanaminhydrochloride;2-Chloro-N-(2-chlorethyl)-ethanamine, Hydrochloride; Bis-(2-chlorethyl)-amine HCl; 2-chloro-N-(2-chloroethyl)ethanamine hydrochloride,and so on.Bis(2-chloroethyl)amine hydrochloride is usually white to light beige powder.
CAS: 821-48-7
Molecular Formula: C₄H₁₀Cl₃N
Molecular Weight: 178.49
EINECS: 212-479-5
Molecular structure:
Melting point: 212-214 °C(lit.)
Water Solubility: Soluble
Sensitive: Hygroscopic
BRN: 3550356

Uses

Bis(2-chloroethyl) (CAS NO.821-48-7) is commonly used as a pharmaceutical intermediate.

Toxicity Data With Reference

1.	hmn-lym 1 mg/L	CRNGDP Carcinogenesis. 5 (1984),163.
2.	hmn-lym 250 µg/L	CRNGDP Carcinogenesis. 5 (1984),163.
3.	mmo-sat 50 µg/plate	PNASA6 Proceedings of the National Academy of Sciences of the United States of America. 72 (1975),979.
4.	ipr-rat LD50:100 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),143.
5.	ims-rat LD₅₀:160 mg/kg	ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. 84 (1975),227.
6.	ihl-mus LCLo:1000 mg/m3/10M	NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report NDCrc-132,July (1942).
7.	scu-mus LD₅₀:20 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224.

RTECS: IA1225000

Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Safety Profile

A poison by inhalation, intraperitoneal, intramuscular, and subcutaneous routes. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NH₃, NO_x, and Cl⁻.

Hazard Codes: Xi Irritant ,T Toxic ,C Corrosive
Risk Statements: 36/37/38-36-34
R36/37/38:Irritating to eyes, respiratory system and skin.
R36:Irritating to eyes.
R34:Causes burns.
Safety Statements: 26-45-36/37/39-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S27:Take off immediately all contaminated clothing.
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant/Toxic
HazardClass: 8
PackingGroup: III
HS Code: 29211980