Reference

Stability of antimalarial fluorenemethanol in soft capsules

Stability of antimalarial fluorenemethanol in soft capsules. Wang, Yunling; Ding, Jianxin; Geng, Rongliang (Inst. Microbiol. Epidemiol., Mil. Acad. Med. Sci., Beijing, Peop. Rep. China). Yaowu Fenxi Zazhi, 4(2), 84-7 (Chinese) 1984. CODEN: YFZADL. ISSN: 0254-1793. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The stability of fluorenemethanol (I) [82186-77-4] soft capsules contg. linoleic acid was studied. TLC indicated that an impurity tentatively identified as I linoleate [92069-16-4] was obsd. The empirical formula was C48H62O2NCl3 an the solidifying point was -52 to -53°. The mol. wt. detd. by mass spectrometry was identical to the theor. value. I and I linoleate were detd. by spectrophotometry at 335 nm. The std. curve was linear to ~40 mg and recoveries were 98.33 and 99.97%, resp. The formation of I linoleate increased with temp. from 60 to 120°.

Artemisinin-based combination therapy reduces expenditure on malaria treatment in KwaZulu Natal, South Africa

Artemisinin-based combination therapy reduces expenditure on malaria treatment in KwaZulu Natal, South Africa. Muheki, Charlotte; McIntyre, Di; Barnes, Karen I.Several substances are used for example 63968-64-9 and 82186-77-4 which are their cas registry numbers. (Health Sciences Faculty, University of Cape Town, S. Afr.). Tropical Medicine & International Health, 9(9), 959-966 (English) 2004 Blackwell Publishing Ltd. CODEN: TMIHFL. ISSN: 1360-2276. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) There is growing international evidence that artemisinin-based combination therapy (ACT) is one of the few effective measures available to 'Roll Back Malaria'. However, concerns about the costs and affordability of ACT are obstacles to its widespread implementation. This paper explores some economic aspects of the implementation of artemether-lumefantrine (AL) to replace sulphadoxine-pyrimethamine (SP) in the KwaZulu Natal (KZN) province, South Africa. Recurrent and capital costs for malaria treatment were compared at baseline and post-intervention for nine clinics and a sentinel rural district hospital. Changes in the unit costs of, and total expenditure on, malaria services were calcd. and the cost effectiveness of AL relative to SP was assessed. The no. of outpatient malaria cases and inpatient admissions both declined by 94% between 2000 and 2002. After accounting for the role of concurrent improvements in vector control, it was conservatively estd. that 36% of the decline in outpatient cases and 46% for inpatient admissions was attributable to changing the first-line drug to AL. Although AL is considerably more expensive than SP, its improved cure rate and reduced malaria transmission resulted in an estd. US$ 201 065 cost saving in 2002 alone for the subdistrict studied. In the context of effective vector control and low efficacy of existing monotherapy, ACT can reduce total expenditure on malaria services. However, the relevance of these findings requires careful consideration in countries with currently effective treatment policies and higher intensity malaria transmission. .