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| CAS No.: | 82410-32-0 |
|---|---|
| Name: | Ganciclovir |
| Article Data: | 36 |
| Molecular Structure: | |
|
|
|
| Formula: | C9H13N5O4 |
| Molecular Weight: | 255.233 |
| Synonyms: | Gancyclovir; |
| EINECS: | 627-054-3 |
| Density: | 1.81 g/cm3 |
| Melting Point: | 250 °C |
| Boiling Point: | 675 °C at 760 mmHg |
| Flash Point: | 362 °C |
| Solubility: | 0.1 M HCl: 10 mg/mL |
| Appearance: | white powder |
| Hazard Symbols: |
 T
|
| Risk Codes: | 46-60-61 |
| Safety: | 53-36/37/39-45 |
| PSA: | 139.28000 |
| LogP: | -1.38970 |
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 852475-26-4MC1568
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- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- 84960-04-3
N2-acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| With ammonium hydroxide In methanol at 20℃; for 17h; | 94% |
| With ammonium hydroxide In methanol at 25℃; for 16h; Yield given; |
- 86357-14-4
9-(1,3-diacetoxy-2-propoxymethyl)-N2-acetylguanine
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| With ammonium hydroxide for 72h; Ambient temperature; | 91% |
| With acetic acid In water; methylamine | 87% |
| With potassium hydroxide at 70℃; for 0.5h; Reagent/catalyst; Microwave irradiation; | 82.8% |
| With methanol; potassium hydroxide at 20℃; for 12h; | 78% |
| With acetic acid In methylamine |
- 82410-31-9
9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| palladium dichloride In ethanol; cyclohexene for 5h; Heating; | 90% |
| With palladium; cyclohexene In ethanol | 87.7% |
| With cyclohexene; palladium In ethanol for 24h; Heating; | 87.7% |
| With cyclohexene; palladium In ethanol |
- 82410-31-9
9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>guanine
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| With ethanol; palladium In cyclohexene for 18h; Heating; | 84% |
- 100675-29-4
N2-acetyl-9-((1,3-pivaloyloxy-2-propoxy)methyl)guanine
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| With sodium methylate In methanol for 40h; Heating; | 72% |
- 131490-72-7
1-<(1,3-dihydroxy-2-propoxy)methyl>-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| With sodium hydroxide; copper(II) sulfate for 1h; Heating; | 61% |
- 1219792-39-8
2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate
A
- 1219792-38-7
2-[(2-amino-1,6-dihydro-6-oxopurin-9-yl)methyloxy]-3-hydroxypropyl 2'-(S)-azido-3'-methylbutanoate
B
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In methanol at 20℃; for 14h; | A 34.5% B 20 %Chromat. |
- 86629-51-8
C23H21N5O6
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| With ammonia In methanol Yield given; |
- 86629-59-6
9-<<2-hydroxy-1-(hydroxymethyl)ethoxy>methyl>-2,6-diamino-purine
- 82410-32-0
ganciclovir
| Conditions | Yield |
|---|---|
| at 25℃; for 18h; adenosine deaminase, pH = 7.5; |
- 88110-89-8
9-<(1-acetoxy-2-hydroxymethyl)ethoxymethyl>guanine
A
- 82410-32-0
ganciclovir
B
- 64-19-7
acetic acid
| Conditions | Yield |
|---|---|
| With New Zealand albino male rabbit cornea homogenate In phosphate buffer at 37℃; for 24h; Kinetics; Further Variations:; Reagents; |
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Specification
1. Introduction of Ganciclovir
Ganciclovir, with the IUPAC Name of 2-Amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one, is one kind of white powder. This chemical has the Classification Code which include Anti-Infective Agents; Antiviral; Antiviral agents; Drug / Therapeutic Agent; Mutation data. Besides, it belongs to the Product Categories which include Bases & Related Reagents; Intermediates & Fine Chemicals; Nucleotides; Pharmaceuticals; API's; Antiviral.
2. Properties of Ganciclovir
Ganciclovir has the following properties: (1)Index of Refraction: 1.76; (2)Molar Refractivity: 57.9 cm3; (3)Molar Volume: 140.5 cm3; (4)Polarizability: 22.95×10-24 cm3; (5)Surface Tension: 86.6 dyne/cm; (6)Density: 1.81 g/cm3; (7)Flash Point: 362 °C; (8)Enthalpy of Vaporization: 104.13 kJ/mol; (9)Boiling Point: 675 °C at 760 mmHg; (10)Melting Point: 250 °C; (11)storage temperature: 2-8 °C; (12)solubility: 0.1 M HCl: 10 mg/mL; (13)Vapour Pressure: 3.82E-19 mmHg at 25 °C.
3. Structure Descriptors of Ganciclovir
You could convert the following datas into the molecular structure:
(1).Canonical SMILES: c12c(ncn1COC(CO)CO)c([nH]c(n2)N)=O
(2).InChI: InChI=1/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
4. Toxicity of Ganciclovir
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | > 150mg/kg (150mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. | |
| dog | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. | |
| mouse | LD50 | intraperitoneal | 1gm/kg (1000mg/kg) | Journal of Medicinal Chemistry. Vol. 26, Pg. 759, 1983. | |
| mouse | LD50 | intravenous | 900mg/kg (900mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. | |
| mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. |
5. Safety Information of Ganciclovir
Common adverse drug reactions >=1% of patients) include: neutropenia, granulocytopenia, thrombocytopenia, fever, nausea, vomiting, dyspepsia, diarrhoea, abdominal pain, flatulence, anorexia, raised liver enzymes, headache, confusion, hallucination, anaemia, pain and phlebitis at injection site (due to high pH), sweating, rash.
Hazard Codes: 
T
Risk Statements: 46-60-61
R46:May cause heritable genetic damage.
R60:May impair fertility.
R61:May cause harm to the unborn child.
Safety Statements: 53-36/37/39-45
S53:Avoid exposure - obtain special instructions before use.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS of Ganciclovir (CAS NO.82410-32-0): MF8407000
6. Use of Ganciclovir
Ganciclovir (CAS NO.82410-32-0) is an antiviral medication used to treat or prevent cytomegalovirus (CMV) infections.