Reference

Azetidinone derivatives

Azetidinone derivatives. (Daiichi Seiyaku Co., Ltd.In this study， 82551-63-1 and 89461-70-1 are also used., Japan). Jpn. Kokai Tokkyo Koho JP 58206582 A2 1 Dec 1983 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D405-04; C07D405-14; C07F007-10. ICA: C07D205-08. ICI: C07D405-04, C07D205-00, C07D309-00; C07D405-14, C07D205-00, C07D209-00, C07D309-00. APPLICATION: JP 82-90427 27 May 1982. DOCUMENT TYPE: Patent CA Section: 26 (Biomolecules and Their Synthetic Analogs) Azetidinone derivs. trans-I (R, R1 = 2-tetrahydropyranyl, Et; Me3CSiMe2, Et; 2-tetrahydropyranyl, phthalimido) were prepd. by reaction of the phenylsulfenyl derivs. II with MeCOC(:N2)CO2CH2C6H4NO2-4 (III). Thus, 330 mg III in C6H6-CH2Cl2 was added to 330 mg trans-II (R = 2-tetrahydropyranyl, R1 = Et) in C6H6-CH2Cl2, a catalytic amt. of Rh(OAc)3 added, and the whole stirred 10 min at room temp. and 4 h under reflux to give 474 mg trans-I (R = 2-tetrahydropyranyl, R1 = Et). .