Detail of "828300-70-5"

Reference

Preparation of imidazo[1,2-a]pyrazin-8-ylamines as Bruton's tyrosine kinase (Btk) inhibitors for the treatment of cancer

Preparation of imidazo[1,2-a]pyrazin-8-ylamines as Bruton's tyrosine kinase (Btk) inhibitors for the treatment of cancer. Currie, Kevin S.; Desimone, Robert W.; Mitchell, Scott; Pippin, Douglas A. (Cellular Genomics, Inc., USA). PCT Int. Appl. WO 2005005429 A1 20 Jan 2005, 58 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D487-04. ICS: A61K031-4985. APPLICATION: WO 2004-US21150 30 Jun 2004. PRIORITY: US 2003-PV484014 30 Jun 2003. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Title compds. I [X = -Z2-Q-R2; Z2 = divalent linking group, i.e., para-phenylene, meta-phenylene, ortho-phenylene, etc.; Q = CON(R4), N(R4)CO; R1 = (un)substituted indole, indazole, benzoxazole, etc.; R2 = alkyl, cycloalkyl, heterocycloalkyl, etc.; R3 = H, alkyl, heterocycloalkyl, etc.; R4 = H, alkyl, (un)substituted Ph etc.] and their pharmaceutically acceptable salts were prepd. For example, p-tert-Bu benzoyl chloride acylation of aniline II, i.e., prepd. from 3,5-dibromo-2-aminopyrazine in 3-steps, afforded claimed imidazopyrazinylamine III. Compds. 828300-70-5 and 219508-62-0 are just another two chemicals used in this study. I are claimed to be useful for the treatment of cancer, autoimmune and/or inflammatory disease or acute inflammatory reaction. .