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Detail of "82834-12-6"

  • CAS Number:
  • 82834-12-6
  • Name:
  • N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanine

  • Molecular Structure:
  • Formula:
  • C10H19NO4
  • Molecular Weight:
  • 217.26
  • Synonyms:
  • L-Norvaline,N-(1-carboxyethyl)-, 1-ethyl ester, (S)-;L-Norvaline,N-[(1S)-1-carboxyethyl]-, 1-ethyl ester;
  • Density:
  • 1.079 g/cm3
  • Melting Point:
  • 145-150 °C
  • Boiling Point:
  • 324.1 °C at 760 mmHg
  • Flash Point:
  • 149.8 °C

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CAS No.82834-12-6 N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanineCompetitive Product

Assay:≥98%  Appearance:White powder  Package:25 Kg/drum  Application:Perindopril ...

N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanine Identification Name N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanine Synonyms (2S)-2-(((S)-1-(ethoxycarbonyl)butyl)amino)propanoic acid Molecular Formula C10H19NO4 Molecular Weight 217.26 CAS Registry Number 82834-12-6

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CAS No.82834-12-6 N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanine

N-((S)-Ethoxycarbonyl-1-butyl)-(S)-Alanine;(2s)-2-(((s)-1-(ethoxycarbonyl)butyl)amino)propanoic acid;N-[(S)-1-Carbethoxybutyl]-(S)-Alanine;N-((S)-1-Ethoxycarbonylbutyl)-L-Alanine;N-((S)ETHOXYCARBONYLBUTYL)-(S)-ALANINE, 98+%;N-((S)Ethoxycarbonylbutyl)-(S)-Alanine;N-((s)-Ethoxycarb

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82834-12-6

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CAS No.82834-12-6 N-[(S)-1-Carbethoxy-1-butyl]-(S)-alanine

Product Name: N-[(S)-1-Ethoxycarbonylbutyl]-(S)-Analine Cas No: 82834-12-6

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intermediate of Perindopril

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Reference

A process for the preparation of perindopril, its analogs and salts using 2,5-dioxooxazolidine intermediate compounds
A process for the preparation of perindopril, its analogs and salts using 2,5-dioxooxazolidine intermediate compounds. Cid, Pau (Adir, Fr.). Eur. Pat. Appl. EP 1279665 A2 29 Jan 2003, 11 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT, IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, SK. (English). (European Patent Organization). CODEN: EPXXDW.In this article, certain chemicals are used. Some of their cas registry numbers are 82834-12-6 and 82834-16-0 CLASS: ICM: C07D209-42. ICS: C07D263-44. APPLICATION: EP 2002-16262 23 Jul 2002. PRIORITY: EP 2001-500197 24 Jul 2001. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 27 Perindopril [(2S,3aS,7aS)-1-[(2S)-2-[(1S)-1-(ethoxycarbonyl)butylamino]propionyl] oc tahydro-1H-indole-2-carboxylic acid] or its analogs or salts were prepd. by treating RcCH(CO2Ra)NHCHRbCO2H (Ra, Rb = C1-4 alkyl, Rc = C1-6alkyl) with X2C:O ( X is a leaving group) to give a 2,5-dioxooxazolidine, which reacts with octahydro-1H-indole-2-carboxylic acid or ester to give the desired product. In an example, N,N'-carbonyldiimidazole was added to a suspension of N-[(S)-1-carbethoxybutyl]-(S)-alanine in CH2Cl2 and the mixt. kept at 0° for 1 h. (2S,3aS,7aS)-octahydroindole-2-carboxylic acid was added at -5°C and the soln. kept at this temp. for 1 h to give 80% perindopril (isolated as the tert-butylamine salt). .
Process for industrially-viable preparation of perindopril erbumine
All Rights Reserved. Process for industrially-viable preparation of perindopril erbumine. 82834-12-6 and 107133-36-8 are also occured in this study. Potluri, Ramesh Babu; Venkata Subramanian, Hariharakrishnan; Mulakala, Atchuta Ramayya Chowdary; Kodali, Hari Prasad (India ). PCT Int. Appl. WO 2006137082 A1 28 Dec 2006,17pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-IN182 29 May 2006. PRIORITY: IN 2005-CH783 23 Jun 2005. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) A novel method for the prepn. of perindopril erbumine [(2S,3aS,7aS)-1-[N-[(S)-1-(ethoxycarbonyl)butyl]-L-alanyl]octahydro-1H- indole-2-carboxylic acid tert-butylamine salt] comprises treating (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid (I) esters with N-[(S)-1-(ethoxycarbonyl)butyl]-L-alanine, followed by deprotection and conversion to the erbumine salt. I benzyl ester hydrochloride was prepd. from hexahydroindoline-2-carboxylic acid hydrochloride by catalytic hydrogenation, followed by esterification and resoln. with dibenzoyl-L-tartaric acid or benzyloxycarbonyl-L-phenylalanine. .
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