Products Categories
| CAS No.: | 82956-11-4 |
|---|---|
| Name: | Nafamostat mesylate |
| Article Data: | 5 |
| Molecular Structure: | |
|
|
|
| Formula: | C21H25N5O8S2 |
| Molecular Weight: | 539.59 |
| Synonyms: | Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate;Ronastat;Nafamostat mesylate (USAN);Nafamostat dimethanesulfonate;Nafamostat mesilate;Benzoic acid,4-[(aminoiminomethyl)amino]-,6- (aminoiminomethyl)-2-naphthalenyl ester,dimethanesulfonate;FUT 175;Futhan;[N-[4-[6-(azaniumylcarbonimidoyl)naphthalen-2-yl]oxycarbonylphenyl]carbamimidoyl]azanium; methanesulfonate;Nafamostat mesilate (JAN);Nafamostat mesylate [USAN];Ronastat (TN);Nafamostat Mesilate(CAS No: 82956-11-4);6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate; |
| EINECS: | 692-168-2 |
| Melting Point: | 259-261 °C |
| Boiling Point: | 637.2 °C at 760 mmHg |
| Flash Point: | 339.1 °C |
| Appearance: | Tan to pale orange solid |
| PSA: | 200.82000 |
| LogP: | 4.90630 |
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
- 90221-55-92-bromo-5-methylbenzaldehyde
- 885590-99-82,3-DIFLUORO-4-IODOBENZALDEHYDE
- 97730-31-9(S)-4'-(2-Methylbutyl)Biphenyl-4-Carbonitrile
- 926293-55-26-Bromo-2-methylpyridine-3-carboxaldehyde
- 82957-06-06-Amidino-2-naphthol methanesulfonate
- 82984-64-31-Propanamine, 3-(trimethoxysilyl)-N,N-bis[3-(trimethoxysilyl)propyl]-
- 82985-35-1Bis(trimethoxysilylpropyl)amine
- 829-85-6Diphenylphosphine
- 83054-80-2N N'-BIS(2 5-DI-T-BU-PHENYL)-3 4 9 10-
- 83056-78-4(S)-3-Methyl-2-oxo-iMidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester
- 831-82-34-Phenoxyphenol
- 832079-33-11,2-BIS(TRIMETHOXYSILYL)DECANE
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
What can I do for you?
Get Best Price
Chemistry
Molecular Structure:
.png)
Molecular Formula: C21H25N5O8S2
Molecular Weight: 539.5819
IUPAC Name: (6-Carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate; methanesulfonic acid
Synonyms of 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4): Nafamostat dimethanesulfonate ; Nafamostat mesylate [USAN] ; 6-Amidino-2-naphthyl p-guanidinobenzoate, dimethanesulfonate ; Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate ; FUT 175 ; Nafamostat mesilate ; Nafamostat mesylate
CAS NO: 82956-11-4
Classification Code: Anticoagulant ; Antifibrinolytic ; Antifibrinolytic agents ; Drug / Therapeutic Agent ; Reproductive Effect
Melting Point: 259-261°C
H bond acceptors: 7
H bond donors: 7
Freely Rotating Bonds: 5
Polar Surface Area: 54.26 Å2
Flash Point: 339.1 °C
Enthalpy of Vaporization: 94.13 kJ/mol
Boiling Point: 637.2 °C at 760 mmHg
Vapour Pressure: 3.9E-16 mmHg at 25°C
Uses
6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4) is used as a non-peptide proteaseinhibitor.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mammal (species unspecified) | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | United States Patent Document. Vol. #4454338, | |
| mammal (species unspecified) | LD50 | oral | 2500mg/kg (2500mg/kg) | United States Patent Document. Vol. #4454338, | |
| mouse | LD50 | intraperitoneal | 269mg/kg (269mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | intravenous | 24400ug/kg (24.4mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | oral | 4600mg/kg (4600mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| mouse | LD50 | subcutaneous | 6180mg/kg (6180mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | intraperitoneal | 162mg/kg (162mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | intravenous | 16400ug/kg (16.4mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | oral | 3050mg/kg (3050mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. | |
| rat | LD50 | subcutaneous | 9200mg/kg (9200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986. |
Safety Profile
RTECS of 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate (CAS NO.82956-11-4): DG2736000
A poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and SOx.