Detail of "83-01-2"

Reference

4-[2-(1,3-Dialkyl-1,2,3,4-tetrahydropyrimidine-2,4-dione-5-carboxamido )ethyl]-1-piperidine sulfonamide

4-[2-(1,3-Dialkyl-1,2,3,4-tetrahydropyrimidine-2,4-dione-5-carboxamido )ethyl]-1-piperidine sulfonamide. Wiedermann, Hans E. (Pfizer Inc., USA). U.S. US 3998828 21 Dec 1976, 8 pp. Division of U.S. 3,936,445. (English). (United States of America). CODEN: USXXAM.There are some reagents with their cas registry numbers 83-01-2 and 62473-16-9 are used in this study. CLASS: IC: C07D401-12. NCL: 260256500R. APPLICATION: US 75-546003 31 Jan 1975. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The title compds. I (R1 = endo-bicyclo[2.2.1]hept-2-ylmethyl, cyclohexyl, 1-adamantyl, endo-7-oxabicyclo[2.2.1]hept-2-ylmethyl, R2 = R3 = Me, R2 = Pr, R3 = Et) were prepd. from II. Thus, 1,3-dimethyl-2,5-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbonyl chloride was treated with 4-(2-aminoethyl)-1-piperidinesulfonamide-HCl, prepd. from 4-(2-phthalimidoethyl)pyridine, to give II (R2 = R3 = Me), which was treated with 1,1-diphenyl-3-(endo-bicyclo[2.2.1]hept-5-en-2-ylmethyl)urea and NaH followed by hydrogenation to give I (R1 = endo-bicyclo[2.2.1]hept-2-yl, R2 = R3 = Me) (III). At 5.0 mg/kg III reduced blood sugar in rats by 19%. .

Stereoselective reduction of oxo groups fixed in the side chains of bicyclic lactones

Stereoselective reduction of oxo groups fixed in the side chains of bicyclic lactones. Van Rheenen, Verlan H. (Upjohn Co., USA). Ger. Offen. DE 2613306 21 Oct 1976, 35 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D307-93. PRIORITY: US 75-565962 7 Apr 1975. DOCUMENT TYPE: Patent CA Section: 24 (Alicyclic Compounds) The lactone I (R = H, R1R2 = O) was treated with an isocyanate to give the corresponding urethane I (R = PhNHCO, Ph2NCO, etc. 62103-57-5 and 83-01-2 are also in the experiment.; R1R2 = O) which was treated with KHB(CHMeEt)3 to give I (R = PhNHCO, etc.; R1 = H, R2 = OH) (II). II was converted by standard methods into 2,3,4,5,6-pentanor-prostaglandin PGF2.alpha.. .