Reference

Interactions of aminophenazone, nicotinamide, 4-aminoantipyrine and sodium p-aminosalicylate with pectic acid

Interactions of aminophenazone, nicotinamide, 4-aminoantipyrine and sodium p-aminosalicylate with pectic acid. Mitterhauszerova, L.; Kralova, K.; Krasnec, L. (Chem. Ustav, Univ. Komenskeho, Bratislava, Czech.). Farm. Obz., 52(11), 501-8 (Slovak) 1983. CODEN: FAOBAS. ISSN: 0014-8172. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The interaction of aminophenazone (I) [58-15-1], nicotinamide (II) [98-92-0], 4-aminoantipyrine (III) [83-07-8], and Na p-aminosalicylate (IV) [133-10-8] with citrus pectin [9000-69-5] and pectin hydrolyzed to varying degrees of esterification was studied to evaluate possible use of pectins as adjuvants in controlled-release formulations. The degree of pectin esterification was neg. correlated with the no. of binding sites for the drugs; assocn. consts. were not affected by the degree of esterification. Assocn. consts. for the drugs followed the order I > IV > III > II; the no. of binding sites followed the order I > III > II = IV. The no. of binding sites was lower than the no. of free CO2H groups. Apparently, factors other than acid-base interactions are involved in detg. binding sites.

Colorimetric determination and stability of sodium novaminesulfonate in solutions

Colorimetric determination and stability of sodium novaminesulfonate in solutions. Altinkurt, Turan (Fac. Pharm., Univ. Hacettepe, Ankara, Turk.). Eczacilik Bul., 18(3), 42-8 (English) 1976. CODEN: ECBUAN. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 Na novaminesulfonate (I) [68-89-3] was sepd. by thin-layer chromatog. on microcryst. cellulose plates using a benzene-Et2NH solvent, scraped from the plates, and detd. colorimetrically at 474 nm. At a concn. of 100 .mu.Several substances with their cas registry numbers 58-15-1 and 519-98-2 may be metioned in this study.g I was detd. with a std. deviation of .+-.0.00175. I loss from 4 com. products, as calcd. by the above method, ranged from 8-17%. I degrdn. products in the com. samples were 4-aminophenazone [83-07-8], 4-dimethylaminophenazone [58-15-1], and 4-methylaminophenazone [519-98-2]. .