Detail of "83-44-3"

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CAS Number:
83-44-3
Name:
Cholan-24-oic acid,3,12-dihydroxy-, (3a,5b,12a)-
Superlist Name:
Deoxycholic acid
Molecular Structure:
Formula:
C₂₄H₄₀O₄
Molecular Weight:
392.58 .
Deleted CAS:
728917-93-9
Synonyms:
5b-Cholan-24-oic acid, 3a,12a-dihydroxy- (8CI);17b-[1-Methyl-3-carboxypropyl]-etiocholane-3a,12a-diol;3a,12a-Dihydroxy-5b-cholan-24-oic acid;3a,12a-Dihydroxy-5b-cholanic acid;3a,12a-Dihydroxy-5b-cholanoicacid;3a,12a-Dihydroxycholanic acid;5b-Cholanic acid-3a,12a-diol;5b-Deoxycholicacid;7-Deoxycholic acid;Cholerebic;Cholic acid, deoxy-;Cholorebic;Degalol;Droxolan;NSC 8797;Pyrochol;Septochol;(3a,5b,12a)-3,12-Dihydroxy-5-cholan-24-oic Acid;(3α,5β,12α)-3,12-dihydroxycholan-24-oic acid;(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,12a-diol;5b-Cholanic acid-3a,12a-diol;5b-Deoxycholic acid;
EINECS:
201-478-5
Density:
1.129 g/cm³
Melting Point:
171-174 °C(lit.)
Boiling Point:
547.148 °C at 760 mmHg
Flash Point:
298.768 °C
Appearance:
white powder
Hazard Symbols:
Xn
Risk Codes:
36/37/38-37-20/21/22
Safety:
26-36-37/39-22 Details

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Reference

Urinary bile acid and bile alcohol excretion does not reflect the genetic polymorphism of debrisoquine hydroxylation: Urinary bile acid and bile alcohol excretion does not reflect the genetic polymorphism of debrisoquine hydroxylation. Karlaganis, G.; Kuepfer, A.; Preisig, R. (Dep. Clin. Pharmacol., Univ. Berne, Bern, Switz.). Br. J. Clin. Pharmacol., 17(4), 470-3 (English) 1984. CODEN: BCPHBM. ISSN: 0306-5251. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Excretion of the major urinary bile alc. 434-13-9 and 81-25-4 which are cas registry numbers of substances are two of reagents here. 27-nor-5b-cholestane-3a,7a,12a,24,25-pentol [78648-95-0], and of cholic acid [81-25-4], chenodeoxycholic acid [474-25-9], deoxycholic acid [83-44-3], and lithocholic acid [434-13-9] was measured in 24 h urine collections of extensive and poor metabolizers of debrisoquine [1131-64-2]. There was no significant difference of the excretion of these cholesterol metabolites between the 2 groups, indicating that cholesterol hydroxylation to bile alcs. and bile acids is probably not controlled by the same genes responsible for the 'debrisoquine-type' hydroxylation polymorphism. .

Effect of preparations of ox gallstone and its major constituent on experimental epidemic encephalitis B infection: Effect of preparations of ox gallstone and its major constituent on experimental epidemic encephalitis B infection. Jin, Enyuan; Zhang, Nengrong (Inst. Virus, Chin. Acad. Med. Sci., Beijing, Peop. Rep. China). Zhongcaoyao, 14(12), 548-50 (Chinese) 1983. CODEN: CTYAD8. ISSN: 0253-2670. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Natural ox gallstone (OG) (20 mg/mL) and its major chem. constituent deoxycholic acid [83-44-3] (0.1%) both showed direct inactivation activity against encephalitis B virus in an in vitro incubation system. The therapeutic effects of natural OG and 3 prepns. contg. the major OG constituents (prepn. I: bovine cholic acid [81-25-4] 15%; swine bile acid 18%, bovine bile salts 4%, cholesterol 2%, inorg. salts and starch; prepn. II: similar to prepn. I with the exception that starch was replaced with bovine Hb; and prepn. III: bilirubin [635-65-4] 0.7%, cholic acid 12.5%, swine deoxycholic acid 15%, cholesterol 2%, inorg. salt 5%, and starch) on mice s.c. inoculated with the encephalitis B virus were tested and compared. The therapeutic effect was in the order: natural OG > prepn. III > prepn. II > prepn. I. The virus inactivation by OG and its prepn. occurred during the toxemic stage and not during the propagation stage. The encephalitis virus inactivation activity of natural OG was greater than any of its constituent prepns. The prepn. contg. bilirubin had greater antiviral activity than prepns. 81-25-4 and 635-65-4 are just another two chemicals used in this study. without it, and the antiviral activity of deoxycholic acid was greater than that of cholic acid. The bovine and swine deoxycholic acids showed comparable antiviral activity. .

Detail of "83-44-3"

Cholan-24-oic acid,3,12-dihydroxy-, (3a,5b,12a)-

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Reference