Reference

Studies on the bile and bile acids

Studies on the bile and bile acids. 2. Effects of the dry powder prepared from pig bile (PBP) and bile acids on cholesterolemia and some factors. Aoki, Kiyoshi; Ito, Yoko; Fujimoto, Yuzo; Kondo, Shigemi; Tachibana, Kuniomi; Kobayashi, Yasuaki (Res Lab., Nissui Pharm. Co., Ltd., Tokyo, Japan). Oyo Yakuri, 14(5), 815-24 (Japanese) 1977. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) PBP, consisting of chenodeoxycholic acid [474-25-9], hyodeoxycholic acid [83-49-8], deoxycholic acid [83-44-3], 6-ketohyodeoxycholic acid [2393-61-5], lithocholic acid [434-13-9], proteins, and lipids, administered to rats receiving cholesterol diet, suppressed the increase of cholesterol levels in the liver and blood, but increased biliary cholesterol level. PBP had no effects on serum glutamic- pyruvic transaminase, glutamic-oxalacetic transaminase and glucose in rats and rabbits.

Nonsulfated bile acids in the liver cells of rats

Nonsulfated bile acids in the liver cells of rats. Studies on the toxicity of chenodeoxycholic acid. Kurtz, W.; Janka, P.; Swoboda, L.; Leuschner, U. (Zent. Inn. Med., Univ. Frankfurt, Frankfurt/Main, Ger.). Verh. Dtsch. Ges. Inn. Med., 83, 496-9 (German) 1977. CODEN: VDGIA2. ISSN: 0070-4067. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Chenodeoxycholic acid [474-25-9] (20 or 90 mg/kg/day) given orally to rats increased total bile acids in liver homogenates, mitochondria, microsomes, cytoplasma, portal vein serum and peripheral serum. The max. increase in bile acids occurred after 9 days. The distribution of acids between hyodeoxycholic acid [83-49-8], a-muricholic acid [2393-58-0], b-muricholic acid [2393-59-1], cholic acid [81-25-4], deoxycholic acid [83-44-3], and lithocholic acid [434-13-9] was altered by chenodeoxycholic acid treatment and depended on the duration of treatment and on the tissue fraction. Generally deoxycholic acid decreased in all compartments; cholic acid decreased only in serum. Lithocholic acid increased in serum and decreased in liver homogenates and subcellular fractions. Peripheral serum bile acid detn. is not sufficient to assess bile acid toxicity.