Detail of "83394-44-9"

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Process for preparation of N-(2-hydroxyethyl)-a-methyl-4-(2-methylpropyl)benzeneacetamide (aminoprofen) by direct amidation

Process for preparation of N-(2-hydroxyethyl)-a-methyl-4-(2-methylpropyl)benzeneacetamide (aminoprofen) by direct amidation. Ginebra Marti, Antonio; Elias Vilarelle, Eduardo (Prodesfarma S. A., Spain). Span. ES 2028601 A6 1 Jul 1992, 6 pp. (Spain).In this experiment, several chemicals are used like 83394-44-9 CODEN: SPXXAD. CLASS: ICM: C07C233-22. ICA: A61K031-165. APPLICATION: ES 91-280 4 Feb 1991. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) The antiinflammatory (no data) aminoprofen, i.e. 4-Me2CHCH2C6H4CHMeCONHCH2CH2OH (I), is prepd. by direct reaction of ibuprofen (II) with excess H2NCH2CH2OH (III) at a temp. between 100° and reflux, with sepn. of H2O of reaction. For example, a mixt. of 0.11 mol II and 0.8 mol III was refluxed for 24 h, cooled, and extd. to yield 86% I. The method avoids toxic and expensive reactants and solvents, and is suitable for industrial application. .