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The effect of fexofenadine on pruritus in a mouse model (HR-ADf) of atopic dermatitis

All Rights Reserved. The effect of fexofenadine on pruritus in a mouse model (HR-ADf) of atopic dermatitis. Akamatsu, H.; Makiura, M.; Yamamoto, N.; Yagami, A.; Shimizu, Y.; Matsunaga, K. (Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan). Journal of International Medical Research, 34(5), 495-504 (English) 2006 Cambridge Medical Publications Ltd.In this article, certain chemicals are used. Some of their cas registry numbers are 51-45-6 and 83799-24-0 CODEN: JIMRBV. ISSN: 0300-0605. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Fexofenadine, a histamine H1-receptor antagonist, is approved for the treatment of pruritus assocd. with atopic dermatitis. The effects of fexofenadine on scratching behavior, and plasma levels of histamine and eotaxin were assessed in a new model of atopic dermatitis. Mice fed a diet low in Mg2+ and Zn2+ (special diet S) were compared with mice on a normal diet (N) or diet S plus fexofenadine HCl for weeks 0 - 10 (S + F0 - 10), 0 - 5 (S + F0 - 5) or 6 - 10 (S + F6 - 10) (seven mice per group). Compared with group N, group S mice showed significantly greater scratching frequency, and plasma histamine and eotaxin concns.; these three variables were significantly lower in group S + F0 - 10 than in group S. Scratching frequency increased when fexofenadine was discontinued. Fexofenadine significantly reduced mast cell and eosinophil nos. Histamine may be important in the pathol. changes seen in this model of atopic dermatitis, suggesting that it might aid future development of antihistamines for the treatment of atopic dermatitis. .

Oral antihistamine therapy influences plasma tryptase levels in adult atopic dermatitis

All Rights Reserved. Oral antihistamine therapy influences plasma tryptase levels in adult atopic dermatitis. Kawakami, Tamihiro; Kaminishi, Kyoko; Soma, Yoshinao; Kushimoto, Tsuneto; Mizoguchi, Masako (Department of Dermatology, St. Marianna University School of Medicine 2-16-1 Sugao, Miyamae-ku, Kanagawa 216-8511, Japan). Journal of Dermatological Science, 43(2), 127-134 (English) 2006 Elsevier Ltd. CODEN: JDSCEI. ISSN: 0923-1811. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Background: Atopic dermatitis (AD) is an allergic skin disease that follows a clin. course of 'flare-up' and remission. Histamine and tryptase are inducers of pruritus and non-sedating second-generation antihistamines, including fexofenadine, are widely used for treatment of allergic skin disorders. Objective: We assessed the efficacy of a second-generation antihistamine in AD patients and examd. its pharmacol. effects on chem. mediators. Methods: The scoring atopic dermatitis (SCORAD) instrument and visual analog scale (VAS) for pruritus were used to assess disease severity in 349 AD patients. Twenty patients with moderate AD symptoms, who had not received any treatment for 2 wk, were randomly assigned into two groups. Ten patients underwent fexofenadine and emollient treatment (Group 1) and 10 received fexofenadine and steroid treatment (Group 2) for 1 wk. SCORAD and VAS for pruritus, and blood histamine and tryptase levels were evaluated before and after treatment. Results: SCORAD and VAS improved in both Group 1 (p = 0.01 and p = 0.006, resp.) and Group 2 (p < 0.Several substances with their cas registry numbers 51-45-6 and 83799-24-0 may be metioned in this study.001 and p = 0.001, resp.). The improvement in Group 1 showed a significant correlation with the diminution rate of blood tryptase levels (SCORAD: r = 0.83 and p = 0.013, resp.; VAS: r = 0.81, p = 0.015, resp.). End-point plasma tryptase levels were significantly lower than baseline levels in Group 2 (p = 0.046). Histamine levels did not show any significant changes in either group. Conclusion: These results suggest that second-generation antihistamine therapy reduces AD pruritus, resulting in the effective clin. treatment for AD. In addn., monitoring tryptase levels during antihistamine therapy in moderate AD treatment may prove to be useful in establishing treatment effects. .