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Detail of "83881-52-1"

  • CAS Number:
  • 83881-52-1
  • Name:

  • Acetic acid,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride(1:2)

  • Superlist Name:
  • Cetirizine hydrochloride
  • Molecular Structure:
  • Formula:
  • C21H25ClN2O3.2(HCl)
  • Molecular Weight:
  • 461.81
  • Synonyms:
  • Alercet;Alerid;Alerlisin;Cesta;Cetirizinedihydrochloride;Cetirizine hydrochloride;Cetrak;Cetrine;Cetrizet;Epirizine;Formistin;Histazine-1;P 071;Reactine;Riztec;Ryzen;Triz;UCB-P 071;Virlix;Zirtec;Zirtek;Zirtin;Zyrlex;Zyrtec;Zyrzine;
  • Melting Point:
  • 110-115 °C
  • Boiling Point:
  • 542.1 °C at 760 mmHg
  • Flash Point:
  • 281.6 °C
  • Appearance:
  • Crystalline solid
  • Hazard Symbols:
  • HarmfulXn, IrritantXi
  • Risk Codes:
  • 22-36/37/38
  • Safety:
  • 26-36 Details
  • Transport Information:
  • UN 3249
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CAS No.83881-52-1 Cetirizine hydrochlorideCompetitive Product

Assay:99%min  Appearance:White crysta...  Package:25kg/drumStorage:Store in a w...  Transportation:According to...

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CAS No.83881-52-1 Cetirizine hydrochlorideCompetitive Product

Assay:99%  Appearance:white or alm...  Package:1kg/can,25kg...

Product Name: Cetirizine Hydrochloride CAS#: 83881-52-1 Appearance : white or almost white crystal powder Assay:99% Packing:1kg/can,25kg/drum

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Cetirizine Hydrochloride is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.

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83881-52-1

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Reference

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine
P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine. Polli, Joseph W.; Baughman, Todd M.; Humphreys, Joan E.; Jordan, Kelly H.; Mote, Angela L.; Salisbury, Jo A.; Tippin, Timothy K.; Serabjit-Singh, Cosette J. (Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Inc., Research Triangle Park, NC 27709, USA). Journal of Pharmaceutical Sciences, 92(10), 2082-2089 (English) 2003 Wiley-Liss, Inc. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concns. of non-sedating (second-generation) antihistamines. 83881-52-1 and 2192-20-3 which are cas registry numbers are also used here. The purpose of this study was to det. the importance of Pgp-mediated efflux on the in vivo brain distribution of the non-sedating antihistamine cetirizine (Zyrtec), and the structurally related sedating (first-generation) antihistamine hydroxyzine (Atarax). In vitro MDR1-MDCKII monolayer efflux assays demonstrated that cetirizine was a Pgp substrate (B ? A/A ? B + GF120918 ratio = 5.47) with low/moderate passive permeability (Papp B ? A = 56.5 nm/s). In vivo, the cetirizine brain-to-free plasma concn. ratios (0.367 to 4.30) were 2.3- to 8.7-fold higher in Pgp-deficient mice compared with wild-type mice. In contrast, hydroxyzine was not a Pgp substrate in vitro (B ? A/A ? B ratio = 0.86), had high passive permeability (Papp B ? A + GF120918=296 nm/s), and had brain-to-free plasma concn. ratios > 73 in both Pgp-deficient and wild-type mice. These studies demonstrate that Pgp-mediated efflux and passive permeability contribute to the low cetirizine brain concns. in mice and that these properties account for the differences in the sedation side-effect profiles of cetirizine and hydroxyzine. .
Liquid chromatographic determination of cetirizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations
Liquid chromatographic determination of cetirizine hydrochloride and paracetamol in human plasma and pharmaceutical formulations. Nagaralli, Basavaraj S.Several substances are used for example 83881-52-1 and 103-90-2 which are their cas registry numbers.; Seetharamappa, Jaldappa; Gowda, Babu G.; Melwanki, Mahaveer B. (Department of Chemistry, Karnatak University, Dharwad 580 003, India). Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 798(1), 49-54 (English) 2003 Elsevier B.V. CODEN: JCBAAI. ISSN: 1570-0232. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 1 An accurate, simple, reproducible and sensitive HPLC method for the detn. of cetirizine hydrochloride (CTZH) and paracetamol (PARA) was developed and validated. The sepn. of CTZH, PARA and Nimesulide (the internal std.) was achieved on a CLC C18 (5 m, 25 cm′4.6 mm i.d) column using UV detection at 230 nm. The mobile phase consisted of MeCN-H2O ( vol./vol.). The linear ranges of detection for CTZH and PARA are 0.715-55 mg/mL (r2 = 0.9985) and 0.55-39 mg/mL (r2 = 0.9957) resp. Intra- and inter-day assay relative std. deviations were <1%. The method was applied successfully to the detn. of binary combination of CTZH and PARA in human plasma and pharmaceutical prepns. There was no interference from drugs commonly administered with CTZH and PARA. The method is linear, reproducible, specific, and rugged. .
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