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84-02-6

Basic Information
CAS No.: 84-02-6
Name: PROCHLORPERAZINE MALEATE
Molecular Structure:
Molecular Structure of 84-02-6 (PROCHLORPERAZINE MALEATE)
Formula: C20H24ClN3S•2C4H4O4
Molecular Weight: 606.096
Synonyms: PROCHLORPERAZINE DIMALEATE;PROCHLORPERAZINE DIMALEATE SALT;PROCHLORPERAZINE MALEATE;2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine,dimaleate;2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin(z)-2-but;2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazinedimaleate;2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazinmaleate(1:2);buccastem
EINECS: 201-511-3
Melting Point: 228ºC
Boiling Point: 524.8 °C at 760 mmHg
Flash Point: 271.2 °C
Solubility: Soluble to 25 mM in DMSO,Very slightly sol in water (<0.1% at 20°). Slightly sol in methanol, ethanol. Practically insol in ether
Appearance: Off-White Powder
Hazard Symbols: HarmfulXn
Risk Codes: 20/21/22
Safety: 36
PSA: 184.22000
LogP: 3.94460
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Chemistry

IUPAC Name: (Z)-But-2-enedioic acid; 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Synonyms: 10H-Phenothiazine, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-, (2Z)-2-butenedioate (1:2) ; 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine (2Z)-but-2-enedioate (1:2) ; 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine di[(2Z)-but-2-enedioate] ; Acide (2Z)-but-2-ènedioïque-2-chloro-10-[3-(4-méthylpipérazin-1-yl)propyl]-10H-phénothiazine (2:1)
Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Antagonists;Dopaminergics;Neurotransmitters
CAS NO: 84-02-6
Molecular Formula of Prochlorperazine hydrogen maleate (CAS NO.84-02-6) : C28H32ClN3O8S
Molecular Weight of Prochlorperazine hydrogen maleate (CAS NO.84-02-6) : 606.09
Molecular Structure of Prochlorperazine hydrogen maleate (CAS NO.84-02-6) :
EINECS: 201-511-3
Flash Point: 271.2 °C
Enthalpy of Vaporization: 79.88 kJ/mol
Boiling Point: 524.8 °C at 760 mmHg
Vapour Pressure: 4.15E-11 mmHg at 25°C 
Appearance:Off-White Powder

Uses

 Prochlorperazine hydrogen maleate (CAS NO.84-02-6) has significant sedative effect, for acute and chronic mental illness, neurosis, and antiemetic.And can also be used for Meniere's syndrome.

Toxicity Data With Reference

1.    

orl-rat LD50:750 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 123 (1959),78.
2.    

scu-mus LD50:320 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,40.
3.    

ivn-mus LD50:142 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 123 (1959),78.

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of Cl, NOx, and SOx.