Detail of "84-96-8"

Reference

Electroanalytical studies of phenothiazine neuroleptics at gold and platinum electrodes

Electroanalytical studies of phenothiazine neuroleptics at gold and platinum electrodes. Bishop, E.; Hussein, W. (Chem. Dep., Univ. Exeter, Exeter EX4 4QD, UK). Analyst (London), 109(3), 229-34 (English) 1984. CODEN: ANALAO. ISSN: 0003-2654. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Coulometry and voltammetry at Pt and Au rotating disk electrodes in aq. solns. were applied to N-substituted phenothiazines (chlorpromazine [50-53-3], fluphenazine [69-23-8], perphenazine [58-39-9], promazine [58-40-2], promethazine [60-87-7], and trimeprazine [84-96-8]). All compds. displayed 3 anodic waves of 1, 1, and 2 electrons; piperazine derivs. consume a further 2 electrons in the side chain. All steps involve EC mechanisms, but all the primary products either disproportionate or react with the solvent and the sole and stable product is the sulfoxide, or the in-chain 1,4-dihydropyrazine for piperazine derivs. Mechanisms were elucidated, and the electrode kinetic parameters were detd. for the first 2 steps of each compd.

Increase in brain tryptophan and 5-hydroxytryptamine on administration of phenothiazines to rats

Increase in brain tryptophan and 5-hydroxytryptamine on administration of phenothiazines to rats. Bender, David A.; Cockcroft, Paul M. (Med. Sch., Middlesex Hosp., London, Engl.). Biochem. Soc. Trans., 5(1), 155-7 (English) 1977. CODEN: BCSTB5. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) I.p. injection of prochlorperazine (I) [58-38-8] (2 mg/rat), chlorprothixene (II) [113-59-7] (4 mg/rat), thioridazine (III) [50-52-2] (6 mg/rat), trimeprazine (IV) [84-96-8], and promethazine (V) [60-87-7] (10 mg/rat for both drugs), but not chlorpromazine (VI) [50-53-3] (1 mg/rat), into rats increased brain tryptophan [73-22-3] concns., whereas all the drugs increased the 5-hydroxytryptamine [50-67-9] concn. of the brain. I, II, III, and VI decreased total serum tryptophan and the proportion of tryptophan bound to serum albumin; IV and V slightly increased total serum tryptophan. IV, but not V, decreased the percentage of freely diffusible tryptophan. V increased the total serum amino acid concn. whereas the other drugs decreased the total amino acid content of serum. The activity of liver tryptophan oxygenase (EC 1.13.11.11) [9014-51-1] was unchanged by I and III treatment, but decreased after treatment with II, IV, V, and VI. These data support the hypothesis that both diffusible serum tryptophan and the concns. of competing amino acids are involved in the regulation of brain 5-hydroxytryptamine synthesis. A decrease in total serum amino acid concn. may be a general effect of phenothiazines.