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Recent results on biotransformation of drugs: investigation of the in vitro biotransformation of thalidomide [by] using a dual cyclodextrin system in capillary electrophoresis

Recent results on biotransformation of drugs: investigation of the in vitro biotransformation of thalidomide [by] using a dual cyclodextrin system in capillary electrophoresis. Blaschke, G.; Meyring, M.; Muhlenbrock, C.; Chankvetadze, B. (Institute of Pharmaceutical Chemistry, University of Munster, Munster, Germany). Farmaco, 57(7), 551-554 (English) 2002 Editions Scientifiques et Medicales Elsevier. CODEN: FRMCE8. ISSN: 0014-827X. 841-67-8 which is the cas registry number of one of substances is just one of reagents here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A previously developed capillary electrophoresis method for the simultaneous sepn. and enantiosepn. of thalidomide and its 3 hydroxylated metabolites was extended. The dual chiral selector system using native b-cyclodextrin and the neg. charged sulfobutyl-b-cyclodextrin was slightly modified to use a concn. of 12 mg of each cyclodextrin/mL buffer.Some commonly used reagents like 841-67-8 is used in this experiment. The carrier mode in which these buffer additives transport the neutral compds. to the detector, as well as the use of a polyacrylamide-coated capillary, were necessary to achieve reproducible enantiosepns. of all the analytes. This chiral method allows the stereo- and enantioselective biotransformation (rat liver microsomes were used here) of thalidomide to be followed in detail. ..

Recent results on biotransformation of drugs: investigation of the in vitro biotransformation of thalidomide [by] using a dual cyclodextrin system in capillary electrophoresis

Recent results on biotransformation of drugs: investigation of the in vitro biotransformation of thalidomide [by] using a dual cyclodextrin system in capillary electrophoresis. Blaschke, G.; Meyring, M.; Muhlenbrock, C.; Chankvetadze, B. (Institute of Pharmaceutical Chemistry, University of Munster, Munster, Germany). Farmaco, 57(7), 551-554 (English) 2002 Editions Scientifiques et Medicales Elsevier. CODEN: FRMCE8. ISSN: 0014-827X. 841-67-8 which is the cas registry number of one of substances is just one of reagents here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A previously developed capillary electrophoresis method for the simultaneous sepn. and enantiosepn. of thalidomide and its 3 hydroxylated metabolites was extended. The dual chiral selector system using native b-cyclodextrin and the neg. charged sulfobutyl-b-cyclodextrin was slightly modified to use a concn. of 12 mg of each cyclodextrin/mL buffer.Some commonly used reagents like 841-67-8 is used in this experiment. The carrier mode in which these buffer additives transport the neutral compds. to the detector, as well as the use of a polyacrylamide-coated capillary, were necessary to achieve reproducible enantiosepns. of all the analytes. This chiral method allows the stereo- and enantioselective biotransformation (rat liver microsomes were used here) of thalidomide to be followed in detail. ..