Reference

Blood and urine concentrations of cyclizine by nitrogen-phosphorus gas-liquid chromatography

Blood and urine concentrations of cyclizine by nitrogen-phosphorus gas-liquid chromatography. Griffin, D. S.; Baselt, R.In this study， 82-92-8 and 841-77-0 are also used. C. (Sch. Med., Univ. California, Davis, CA 95616, USA). J. Anal. Toxicol., 8(2), 97-9 (English) 1984. CODEN: JATOD3. ISSN: 0146-4760. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Gas-liq. chromatog. with N-P detection was used to analyze blood and urine from a volunteer who ingested 50 mg of cyclizine (I) [82-92-8]. A peak blood cyclizine concn. of 69 ng/mL was obsd. 2 h after drug administration, and the levels declined thereafter in a biphasic manner, with estd. half-lives of 7 and 24 h for the early and late phases, resp. The peak urine cyclizine concn. of 12.5 ng/mL was achieved at 4 h after administration; only 0.01% of the dose was excreted in the 24 h urine. Norcyclizine [841-77-0] was not obsd. in blood or urine; however, the detectability of the method for this metabolite is poor relative to the parent drug. .

Piperazines as model substrates for oxidations

All Rights Reserved. Piperazines as model substrates for oxidations. Moehrle, H.; Azodi, K. (Institut fuer Pharmazeutische Chemie, Heinrich-Heine-Universitaet, Duesseldorf, Germany). Pharmazie, 61(10), 815-822 (German) 2006 Govi-Verlag Pharmazeutischer Verlag GmbH. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Piperazine derivs. when being oxidized by mercury-EDTA behave unusually. Due to the reactive cyclic enediamine intermediates as aza-analogous reductones and to the carbonyl compds. resulting from dehydrogenation in the side chain, there existed a high tendency of polymn. 1-Benzylpiperazines generated the piperazine-2,3-diones in medium yields. From 1-benzhydrylpiperazine resulted a mixt. of a piperazine-2,3-dione and a piperazine-3-one.In this experiment, several chemicals are used like 841-77-0 and 918428-83-8 The 1,4-bis-substituted piperazines reacted more differently because of the symmetry and the preferred direction of the dehydrogenation into the cycle, leading to the corresponding diones in good yields. A mechanism for the reactions was proposed. .