Detail of "84485-00-7"

CAS Number:
84485-00-7
Name:
Sibutramine hydrochloride anhydrous
Molecular Structure:
Formula:
C₁₇H₂₇Cl₂N
Molecular Weight:
316.31
Synonyms:
Cyclobutanemethanamine,1-(4-chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)-, hydrochloride (9CI);BTS 54524;Reductil;Sibutraminehydrochloride;1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride;Meridia;Sibutramine HCl;Yeduc;
Density:
1.026 g/cm³
Melting Point:
190-200 °C
Boiling Point:
348.119 °C at 760 mmHg
Flash Point:
164.337 °C

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Reference

Reduced left ventricular mass after treatment of obese patients with sibutramine: an echocardiographic multicentre study: All Rights Reserved. Reduced left ventricular mass after treatment of obese patients with sibutramine: an echocardiographic multicentre study. Wirth, A.; Scholze, J.; Sharma, A. M.; Matiba, B.; Boenner, G. ( Teutorburger-Wald-Klinik, Bat Rothenfelde, Germany). Diabetes, Obesity and Metabolism, 8(6), 674-681 (English) 2006 Blackwell Publishing Ltd. CODEN: DOMEF6. ISSN: 1462-8902. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Aim: In obesity, left ventricular hypertrophy is frequently obsd., esp. in the presence of hypertension. Following body wt. redn., the left ventricular mass (LVM) is reduced. It is not known to which extent this occurs after treatment with sibutramine. Methods: In this multicentre trial, 195 male and female patients (18-65 years of age, body mass index 30-40 kg/m2) were treated for 12 wk with either 15 mg/day sibutramine or placebo. They were advised to follow mildly hypocaloric reducing diets. Exclusion criteria were blood pressure values >180/110 mmHg and tachycardia (heart rate 3100 beats/min). Echocardiog. in M-mode was performed to det. LVM as well as systolic function. Results: Body wt. was reduced by 6.9 ± 0.3 kg under sibutramine and by 2.Several substances like 84485-00-7 may be metioned in this study.1 ± 0.6 kg under placebo; body fat was reduced by 5.2 ± 0.4 kg and 1.6 ± 0.7 kg resp. In the sibutramine group, LVM was reduced by 10.9 ± 24.2 g; LVM indexed for body surface area was reduced by 2.3 ± 11.8 g/m2 and LVM indexed for body height was reduced by 2.5 ± 6.0 g/m2.7. In the placebo group, LVM and LVM indexes were not significantly changed. Changes in LVM correlated with redns. in body wt. and initial LVM but not with changes in blood pressure or heart rate. Conclusions: After 3 mo of treatment with sibutramine, obese patients lost about three times as much of body wt. and LVM than patients treated with placebo. Therefore, sibutramine may be recommended not only to reduce body wt. but also to obtain a regression of the LVM in obese patients with and without hypertension. .

Determination of sibutramine hydrochloride by derivative fluorescence spectroscopy: All Rights Reserved. Determination of sibutramine hydrochloride by derivative fluorescence spectroscopy. Qin, Zong-hui; Liu, Yan; Tan, Rong; Pu, Li-jun (Dept. of Chemistry and Environmental Science, Fuling Normal College, Fuling 408003, Peop. Rep. China). Fenxi Shiyanshi, 25(4), 9-12 (Chinese) 2006 Fenxi Shiyanshi Bianjibu. CODEN: FENSE4. ISSN: 1000-0720. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 80 Based on deriv. reaction, a new deriv. fluorescence method was developed for the detn. of sibutramine hydrochloride. The deriv. system, reaction conditions and stability of the products were studied in detail. It was assured that the mixt. of acetic anhydride and malonic acid reacted with sibutramine hydrochloride for 15 min at 75 °C, and the product had high fluorescence with lex = 456 nm and lem = 496 nm. In the selected conditions, the fluorescent intensity was linearly related to concn. of sibutramine hydrochloride in the range of 0.11-9.5 mg/mL with detection limit of 13.4 ng/mL and recovery rate of 95. 84485-00-7 and 141-82-2 which are cas registry numbers of substances are two of reagents here.4-104.2%. The method was applied to the detn. of sibutramine hydrochloride in qumei capsules with satisfactory results. .

Detail of "84485-00-7"

Sibutramine hydrochloride anhydrous

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CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

CAS No.84485-00-7 Sibutramine hydrochloride anhydrous

Reference